Individual Study / VCSIP

Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function

Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function

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Initiatives -
 The purpose of this ECHO application is to combine the offspring from the prenatal cohorts of two RCTs studying the effects of vitamin C supplementation(500 mg per day) to pregnant smokers on offspring respiratory outcomes and to determine if the innovative therapy of maternal vitamin C supplementation during pregnancy leads to prolonged improvements on offspring’s pulmonary function tests (PFTs) and respiratory health.
Start Year
2007
End Year
2023
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Investigators Contacts
  • MD. Prof. Cynthia McEvoy
    Oregon Health & Science University

Design

Study design
Clinical trial cohort

Marker Paper

McEvoy CT, Shorey-Kendrick LE, Milner K, Schilling D, Tiller C, Vuylsteke B, Scherman A, Jackson K, Haas DM, Harris J, Schuff R, Park BS, Vu A, Kraemer DF, Mitchell J, Metz J, Gonzales D, Bunten C, Spindel ER, Tepper RS, Morris CD. Oral Vitamin C (500 mg/d) to Pregnant Smokers Improves Infant Airway Function at 3 Months (VCSIP). A Randomized Trial. Am J Respir Crit Care Med. 2019 May 1;199(9):1139-1147. doi: 10.1164/rccm.201805-1011OC.

PUBMED 30522343

Recruitment

Sources of Recruitment
  • Families

Number of participants

Number of participants
252
Number of participants with biosamples

Access

Availability of data and biosamples

Data
Biosamples
Other