Individual Study / van Eijndhoven_Transl Psychiatry_2016

Bilateral ECT induces bilateral increases in regional cortical thickness (The GEMRIC Nijmegen, the Netherlands center)

Bilateral ECT induces bilateral increases in regional cortical thickness (The GEMRIC Nijmegen, the Netherlands center)

Initiatives -
Electroconvulsive therapy (ECT) is the most effective treatment for patients suffering from severe or treatment-resistant major depressive disorder (MDD), but, its underlying neurobiological mechanisms remain unclear. One line of evidence indicates that the seizures produced by ECT induce or stimulate neuroplasticity effects. This study aimed to explore how these seizures affect the cortex and the effect of ECT on cortical thickness.
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Members

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Investigators Contacts
  • Dr. Philip Van Eijndhoven
    Radboud University Medical Center

Design

Study design
Patients' cohort
Follow Up
2 time points

Marker Paper

van Eijndhoven P, Mulders P, Kwekkeboom L, et al. Bilateral ECT induces bilateral increases in regional cortical thickness. Transl Psychiatry. 2016;6(8): e874. doi:10.1038/tp.2016.139

PUBMED 27552587

Recruitment

Sources of Recruitment
  • Individuals

Number of participants

Number of participants
45
Number of participants with biosamples
Supplementary Information
23 patients (8 male/15 female; age 50.7±8.5 years) with treatment-resistant MDD and 22 sex- and age-matched healthy controls (8 male/14 female; mean age=50.8±8.8 years)

Access

Availability of data and biosamples

Data
Biosamples
Other

Availability of access information

On the study website : https://mmiv.no/gemric/