Bilateral ECT induces bilateral increases in regional cortical thickness (The GEMRIC Nijmegen, the Netherlands center)
Electroconvulsive therapy (ECT) is the most effective treatment for patients suffering from severe or treatment-resistant major depressive disorder (MDD), but, its underlying neurobiological mechanisms remain unclear. One line of evidence indicates that the seizures produced by ECT induce or stimulate neuroplasticity effects. This study aimed to explore how these seizures affect the cortex and the effect of ECT on cortical thickness.
- Study design
- Patients' cohort
- Follow Up
- 2 time points
van Eijndhoven P, Mulders P, Kwekkeboom L, et al. Bilateral ECT induces bilateral increases in regional cortical thickness. Transl Psychiatry. 2016;6(8): e874. doi:10.1038/tp.2016.139
- Sources of Recruitment
Number of participants
- Number of participants
- Number of participants with biosamples
- Supplementary Information
- 23 patients (8 male/15 female; age 50.7±8.5 years) with treatment-resistant MDD and 22 sex- and age-matched healthy controls (8 male/14 female; mean age=50.8±8.8 years)
No coverage data about the variables classifications are available.