Bilateral ECT induces bilateral increases in regional cortical thickness (The GEMRIC Nijmegen, the Netherlands center)
Initiatives
-
Electroconvulsive therapy (ECT) is the most effective treatment for patients suffering from severe or treatment-resistant major
depressive disorder (MDD), but, its underlying neurobiological mechanisms remain unclear. One line of evidence
indicates that the seizures produced by ECT induce or stimulate neuroplasticity effects. This study aimed to explore how these seizures affect the cortex and the effect of ECT on cortical thickness.
Visit van Eijndhoven_Transl Psychiatry_2016
| Investigators | Contacts |
|---|---|
|
Design
- Study design
- Patients' cohort
- Follow Up
- 2 time points
Marker Paper
van Eijndhoven P, Mulders P, Kwekkeboom L, et al. Bilateral ECT induces bilateral increases in regional cortical thickness. Transl Psychiatry. 2016;6(8): e874. doi:10.1038/tp.2016.139
PUBMED 27552587
Recruitment
- Sources of Recruitment
-
- Individuals
Number of participants
- Number of participants
- 45
- Number of participants with biosamples
- Supplementary Information
- 23 patients (8 male/15 female; age 50.7±8.5 years) with treatment-resistant MDD and 22 sex- and age-matched healthy controls (8 male/14 female; mean age=50.8±8.8 years)
Access
Availability of data and biosamples
| Data | |
| Biosamples | |
| Other |
Availability of access information
On the study website : https://mmiv.no/gemric/