Individual Study / UBCoS

The Uppsala Birth Cohort Multigenerational Study

The Uppsala Birth Cohort Multigenerational Study

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Initiatives -
The unique multigenerational data base, Uppsala Birth Cohort Multigeneration Study (UBCoS), was established in 2004 by combining existing data on a representative and well-defined cohort of 14,192 males and females born in Uppsala from 1915-1929 with information on descendants of the original cohort members obtained from routine data registers. To date, the study has been further developed by additional data collection in school archives and records from Census 1930 and the period of follow-up extended till end of year 2010. Further data collection is currently ongoing. The main objective is to investigate how social inequalities in health are formed over the life-course and regenerated in each new generation.
Start Year
2010
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Members

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Investigators Contacts
  • Prof Ilona Koupil
    Karolinska Institutet

Design

Study design
Other : Multi-generational cohort study
Follow Up
Continuous follow-up in archives and registers 1915-2009
Supplementary Information
The data base contains information about families spanning up to five generations, including the 14 192 original cohort members (generation 1), their 20 790 biological children, 37 458 grandchildren and 24 618 great grandchildren born up to 2009. Data come from sources including archived obstetric and school records, the censuses of 1930, 1960, 1970, 1980 and 1990, LOUISE/LISA (register with data from the labour market, educational and social sectors for the years 1985-2008), the Education register, Medical Birth Registry, Inpatient registry, Cancer and Death registry and the Conscript registry. Additional information collected manually on social and early life characteristics (mother’s civil status, family size and social class of the family at birth, birth weight, length of gestation, mother’s age at menarche and pelvic size, complications in pregnancy and during delivery) and deaths before 1961 is available for the original cohort born 1915–1929 and their parents. Moreover, within each of these data sources multiple indicators were obtained capturing different facets of a particular socioeconomic domain (e.g. individual income plus family income). Finally, archive data includes raw data on occupation, providing scope to explore new classifications such as the recently-proposed Historical International Standard Classification of Occupations. For the purposes of the ATHLOS project and because of the differences in the study design with the other longitudinal studies (based on questionnaires, not only in registers), baseline and follow-ups were considered at the date of census registers in the years 1960, 1970, 1980 and 1990, and LISA registers in 2000 and 2008.

Marker Paper

Koupil I. The Uppsala studies on developmental origins of health and disease. J Intern Med 2007;261(5):426-36. Koupil I, Goodman A. Health Equity: A life course approach. Public Service Review: European Union 2011; 11:382-3.

PUBMED 17444882

Recruitment

Sources of Recruitment
  • Individuals
  • Families

Number of participants

Number of participants
61,613
Number of participants with biosamples
Supplementary Information
The multigenerational study comprises over 150,000 individuals, including cohort members, parents, descendants and partners. For the purposes of the ATHLOS project, data from the first and second generation were selected including partners of the participants in each generation. The number of participants are around 62,000 (14,192 participants in the 1st generation, 20,790 participants in the 2nd generation, and the rest are partners of the participants).

Access

Availability of data and biosamples

Data
Biosamples
Other

Timeline

Populations

Representative and well-defined cohort of 14,192 males and females born in Uppsala University Hospital from 1915-1929
Selection Criteria
Minimum age
0
Newborns
Twins
Countries
  • Sweden
Territory
Uppsala
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample

Number of participants

Number of participants
14,192
Number of participants with biosamples
Supplementary Information
The number of participants are 14,192, but sample size is higher because partners of participants were also included in the cohort.
The population consists of 21,070 biological children from the participants in the 1st generation population. They could be born anywhere from 1932 onwards, including potentially outside of Sweden as long as they were ultimately registered in Sweden.
Selection Criteria
Minimum age
0
Newborns
Twins
Countries
  • Sweden
Territory
Uppsala
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • Specific population
Specific Population
  • Other specific population : Biological children from the 1st generation population

Number of participants

Number of participants
20,790
Number of participants with biosamples
Supplementary Information
The number is higher than 20,790 because partners of participants were also included in the cohort.