Individual Study / TIDES

Prenatal and eraly childhooh pathways to health: an integrated model of chemical and social exposures, biological mechanisms and sex-specific effects on neurodevelopment and respiratory outcomes

Prenatal and eraly childhooh pathways to health: an integrated model of chemical and social exposures, biological mechanisms and sex-specific effects on neurodevelopment and respiratory outcomes

Initiatives -
Our study is powered to assess interactive effects of chemical and non-chemical stressors and will be the first study to characterize how prenatal environmental exposures relate to placental transcriptome pathways in relation to childhood health outcomes. This represents a significant scientific advance in testing DOHaD hypotheses. Major contributions to the ECHO Consortium include: 1. The development of a state of the art national model of air pollution 2. A large, diverse pregnancy cohort with extensive biorepositories and extant prenatal and postnatal biomarkers, placental transcriptome, psychosocial and environmental data 3. An experienced, interdisciplinary team that will contribute meaningfully to the ECHO program of work.
Start Year
2016
End Year
2023
Funding
National Institutes of Health
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Members

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Investigators Contacts
  • MD. PhD. Prof Catherine J. Karr
    University of Washington

Design

Study design
Population cohort
Follow Up
Childhood neurodevelopment and airway health (at ages 4-6, 8-9, and 10-11 years).Data collection in pregnancy was nested in clinical care, with questionnaire and specimen collection conducted during routine prenatal visits at < 18, 18-25, and > 25 weeks gestation.

Marker Paper

Padula AM, Monk C, Brennan PA, Borders A, Barrett ES, McEvoy CT, Foss S, Desai P, Alshawabkeh A, Wurth R, Salafia C, Fichorova R, Varshavsky J, Kress A, Woodruff TJ, Morello-Frosch R; program collaborators for Environmental influences on Child Health Outcomes. A review of maternal prenatal exposures to environmental chemicals and psychosocial stressors-implications for research on perinatal outcomes in the ECHO program. J Perinatol. 2020 Jan;40(1):10-24. doi: 10.1038/s41372-019-0510-y. Epub 2019 Oct 15.

PUBMED 31616048

Recruitment

Sources of Recruitment
  • Families

Number of participants

Number of participants
3,235
Number of participants with biosamples
Supplementary Information
Eligible women were ≥ 18 years old, < 18 weeks pregnant, had a pregnancy that is not medically threatened, and planned to deliver at NYU Langone Hospital-Manhattan, Bellevue Hospital, or NYU Langone Hospital-Brooklyn.

Access

Availability of data and biosamples

Data
Biosamples
Other