Individual Study / The GIRAFA Registr

The GIRAFA Registr

The GIRAFA Registr

Initiatives -
The primary hypothesis is that a risk score comprised of approximately 10 single nucleotide polymorphisms (SNPs) that are associated with atrial fibrillation at the Genome Wide Association Study (GWAS) level is associated with the development of atrial fibrillation among previously undiagnosed patients at high risk for atrial fibrillation. A current example of these SNPs is shown in Table 1. As a secondary hypothesis, we will test the association between atrial fibrillation diagnosed in this study with a subset of SNPs reported to be associated with atrial fibrillation and with fine-mapping SNPs. We will also test the association between atrial fibrillation of less than and greater than 30 seconds and a panel of approximately 10 SNPs.
Start Year
End Year
Scripps Translational Science Institute
Visit The GIRAFA Registr


Investigators Contacts
  • Dr. Eric Topol
    The Scripps Research Institute


Study design
Patients' cohort

Marker Paper

Muse ED, Wineinger NE, Spencer EG, et al. Validation of a genetic risk score for atrial fibrillation: A prospective multicenter cohort study. PLoS Med. 2018;15(3):e1002525. Published 2018 Mar 13. doi:10.1371/journal.pmed.1002525

PUBMED 29534064


Sources of Recruitment
  • Individuals

Number of participants

Number of participants
Number of participants with biosamples
Supplementary Information
Over 18 years old with symptoms of high clinical suspicion for atrial fibrillation prompting referral for ambulatory cardiac rhythm monitoring for potential atrial fibrillation.


Availability of data and biosamples