The GIRAFA Registr
Initiatives
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The primary hypothesis is that a risk score comprised of approximately 10 single nucleotide polymorphisms (SNPs) that are associated with atrial fibrillation at the Genome Wide Association Study (GWAS) level is associated with the development of atrial fibrillation among previously undiagnosed patients at high risk for atrial fibrillation. A current example of these SNPs is shown in Table 1. As a secondary hypothesis, we will test the association between atrial fibrillation diagnosed in this study with a subset of SNPs reported to be associated with atrial fibrillation and with fine-mapping SNPs. We will also test the association between atrial fibrillation of less than and greater than 30 seconds and a panel of approximately 10 SNPs.
- Start Year
- 2013
- End Year
- 2018
- Funding
- Scripps Translational Science Institute
Visit The GIRAFA Registr
| Investigators | Contacts |
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Design
- Study design
- Patients' cohort
Marker Paper
Muse ED, Wineinger NE, Spencer EG, et al. Validation of a genetic risk score for atrial fibrillation: A prospective multicenter cohort study. PLoS Med. 2018;15(3):e1002525. Published 2018 Mar 13. doi:10.1371/journal.pmed.1002525
PUBMED 29534064
Recruitment
- Sources of Recruitment
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- Individuals
Number of participants
- Number of participants
- 928
- Number of participants with biosamples
- Supplementary Information
- Over 18 years old with symptoms of high clinical suspicion for atrial fibrillation prompting referral for ambulatory cardiac rhythm monitoring for potential atrial fibrillation.
Access
Availability of data and biosamples
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| Biosamples | |
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