Individual Study / Sweden (Uppsala)

Gustafsson_Brit J Cancer_1995

Gustafsson_Brit J Cancer_1995

Initiatives -
Main goals aim to: 1. quantify the absolute and relative risks for CIS and invasive cancer (ICC) as a function of time since detected HPV infection, and of viral load of HPV 16; 2. compare the relative risk functions between CIS and ICC, and assess whether Chlamydia trachomatis infection, and/or HLA haplotype, modulates the final outcome of HPV infection in terms of cervical cancer risk and whether such modulation is mediated via an effect on HPV viral load. 3. Describe which subtype/variant lineages of HPV16 – the dominant oncogenic HPV type – are found in the study 4. Investigate prospectively whether conserved status and/or hypovariability of the HPV16 E7 gene typically precedes diagnosis of CIS or ICC.
Start Year
1969
End Year
1995
Funding
NIH, Bethesda, MD (NR 1 RO1 CA61197-01A3), by grants from the Swedish Cancer Society, and by the Danish National Science Foundation.
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Members

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Investigators Contacts
  • Nathalie Ylitalo
    Karolinska Institutet
  • Project coordinator Karin Sundström
    Karolinska Institutet

Design

Study design
Population cohort
Follow Up
26 years follow up

Marker Paper

Gustafsson, L., Sparén, P., Gustafsson, M., Wilander, E., Bergström, R., and Adami , H‐O. Efficiency of organised and opportunistic cytological screening for cancer in situ of the cervix. Brit. J. Cancer, 72, 498– 505 (1995)

Recruitment

Sources of Recruitment
  • Individuals

Number of participants

Number of participants
118,890
Number of participants with biosamples
Supplementary Information
Women 30–49 year

Access

Availability of data and biosamples

Data
Biosamples
Other