Gustafsson_Brit J Cancer_1995
Initiatives
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Main goals aim to:
1. quantify the absolute and relative risks for CIS and invasive cancer (ICC) as a function of time since detected HPV infection, and of viral load of HPV 16;
2. compare the relative risk functions between CIS and ICC, and assess whether Chlamydia trachomatis infection, and/or HLA haplotype, modulates the final outcome of HPV infection in terms of cervical cancer risk and whether such modulation is mediated via an effect on HPV viral load.
3. Describe which subtype/variant lineages of HPV16 – the dominant oncogenic HPV type – are found in the study
4. Investigate prospectively whether conserved status and/or hypovariability of the HPV16 E7 gene typically precedes diagnosis of CIS or ICC.
- Start Year
- 1969
- End Year
- 1995
- Funding
- NIH, Bethesda, MD (NR 1 RO1 CA61197-01A3), by grants from the Swedish Cancer Society, and by the Danish National Science Foundation.
Visit Sweden (Uppsala)
| Investigators | Contacts |
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Design
- Study design
- Population cohort
- Follow Up
- 26 years follow up
Marker Paper
Gustafsson, L., Sparén, P., Gustafsson, M., Wilander, E., Bergström, R., and Adami , H‐O. Efficiency of organised and opportunistic cytological screening for cancer in situ of the cervix. Brit. J. Cancer, 72, 498– 505 (1995)
Recruitment
- Sources of Recruitment
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- Individuals
Number of participants
- Number of participants
- 118,890
- Number of participants with biosamples
- Supplementary Information
- Women 30–49 year
Access
Availability of data and biosamples
| Data | |
| Biosamples | |
| Other |