Individual Study / STEMI GIPS-III

Glycometabolic Intervention as adjunct to Primary percutaneous intervention in ST elevation myocardial infarction

Glycometabolic Intervention as adjunct to Primary percutaneous intervention in ST elevation myocardial infarction

Initiatives -
To evaluate the efficacy of a 4 month metformin treatment on preservation of LVEF (left ventricular ejection fraction) in non-diabetic STEMI patients (presenting ST elevation myo-cardial infarction) requiring primary PCI (percutaneous coronary intervention ) treatment.
Start Year
2011
End Year
2015
Funding
This study is supported by a grant of the Netherlands Organization for Health Research and Development (ZonMW; project no. 40-41200-98-9139).
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Members

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Investigators Contacts
  • Dr. Iwan C.C. Van der Horst
    University of Groningen
  • Dr. Chris P.H. Lexis
    University Medical Center Groningen

Design

Study design
Clinical trial cohort
Follow Up
Subjects are scheduled for return visits at 2 weeks,2 months, 4 months, and 12 months after hospital discharge. During every visit examination, assessment of clinical events and 12-lead electrocardiography are performed. During the 4 month visit the amount of study drug received, dispensed, and consumed will be recorded.

Marker Paper

Lexis CP, van der Horst IC, Lipsic E, van der Harst P, van der Horst-Schrivers AN, Wolffenbuttel BH, de Boer RA, van Rossum AC, van Veldhuisen DJ, de Smet BJ; GIPS-III Investigators. Metformin in non-diabetic patients presenting with ST elevation myocardial infarction: rationale and design of the glycometabolic intervention as adjunct to primary percutaneous intervention in ST elevation myocardial infarction (GIPS)-III trial. Cardiovasc Drugs Ther. 2012 Oct;26(5):417-26. doi: 10.1007/s10557-012-6413-1.

PUBMED 22968678

Recruitment

Sources of Recruitment
  • Individuals

Number of participants

Number of participants
380
Number of participants with biosamples
Supplementary Information
Non-diabetic STEMI patients

Access

Availability of data and biosamples

Data
Biosamples
Other