Individual Study / SMWHS

Seattle Midlife Women’s Health Study

Seattle Midlife Women’s Health Study

Initiatives -
1. The initial phase of SMWHS (1989 – 1996) was designed to test a model relating MT status, stress exposure, socialization for midlife, personal and social factors modulating mid-life experiences, reproductive health history, and health behaviors to health status and health-seeking behavior in midlife women between the ages of 35 and 55. 2. The second phase (1996 – 2001) focused on the menopausal transition (MT) and its relationship to symptoms, altered ovarian function, perceived stress and stress arousal, as well as symptom management. 3. Phase 3 (2002 – 2006) continued to focus on symptoms as the primary endpoints. In addition to linking the symptoms to endocrine patterns, the effect of gene polymorphisms in estrogen synthesis, metabolism and receptor genes was added to the aims. 4. A fourth and final phase of data collection (2007 – 2013) consisted of a combination of the aims for the three prior phases of funding. *Note: All published information has been collected from the article referenced in the Marker Paper box below. Therefore, there may be variations with more advanced versions of the study.*
Start Year
End Year
National Institute for Nursing Research, NIH, R01- NR 04141 need title; National Institute for Nursing Research, NIH, P50-NR-02323, P30-NR04001 Center for Women’s Health Research; National Institute of Environmental Health Sciences P30-07033 Center for Ecogenetics and Environmental Health; National Institute for Nursing Research R21-NR012218 Symptom Clusters during the Menopausal Transition and Early Postmenopause; Pfizer, Inc., Medical Division Research Grant (Pfizer, Inc, Medic alDivision. #WS1752232. Urinary Incontinence during the Menopausal Transition and Early Postmenopause; Research Intramural Funding Program, University of Washington School of Nursing.


Investigators Contacts
  • Dr Nancy Fugate Woods
    University of Washington


Study design
Population cohort
Follow Up
Following the baseline study (phase 1) the cohort has been reassessed approximately every 6 years.

Marker Paper

Woods NF, Mitchell ES. The Seattle Midlife Women's Health Study: a longitudinal prospective study of women during the menopausal transition and early postmenopause. Womens Midlife Health. 2016 Nov 9;2:6. doi: 10.1186/s40695-016-0019-x.

PUBMED 30766702


Sources of Recruitment
  • Individuals

Number of participants

Number of participants
Number of participants with biosamples


Availability of data and biosamples