Individual Study / SABRE

Southall And Brent REvisited Study

Southall And Brent REvisited Study

Initiatives -
The study examines how mid-life health, lifestyle and social factors affect health in older age and aims to improve understanding of the reasons underlying ethnic group differences in health. The aim is to address the following primary research questions: 1. Is the greater risk of CHD in Indian Asians explained by a hyperglycaemia-associated adverse lipid and lipoprotein profile compared with Europeans?; 2. Is the greater risk of stroke and magnetic resonance imaging (MRI)-detected subclinical cerebral infarct in African Caribbeans explained by hyperglycaemia-associated loss of nocturnal blood pressure dipping compared with Europeans?; 3. Does subclinical circulatory disease differ by ethnicity, and if so, is this predicted and explained by differences in expression of the cardiometabolic syndrome?; 4. Do current thresholds for risk-factor interventions need modifying for UK ethnic minority groups? **General enquires: sabre@ucl.ac.uk**
Funding
British Heart Foundation and the Wellcome Trust.
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Members

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Investigators Contacts
  • Professor Nishi Chaturvedi
    University College London

Design

Study design
Population cohort
Follow Up
Since the baseline studies, participants have been flagged for mortality by the Office for National Statistics and analyses of death certificate data have been performed. A pilot postal follow-up in 176 people randomly selected from both baseline studies was conducted in 2004. This feasibility assessment informed the grant application for follow-up of the entire study population. The first follow-up of survivors was done in 2008-2011.

Marker Paper

Tillin T, Forouhi NG, McKeigue PM, Chaturvedi N; SABRE Study Group. Southall And Brent REvisited: Cohort profile of SABRE, a UK population-based comparison of cardiovascular disease and diabetes in people of European, Indian Asian and African Caribbean origins. Int J Epidemiol. 2012 Feb;41(1):33-42. doi: 10.1093/ije/dyq175. Epub 2010 Nov 1.

PUBMED 21044979

Recruitment

Sources of Recruitment
  • Individuals

Number of participants

Number of participants
4,972
Number of participants with biosamples

Access

Availability of data and biosamples

Data
Biosamples
Other

Availability of access information

On the study website : https://www.sabrestudy.org/

By contacting the study representative