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Rotterdam Study

Rotterdam Study

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Start Year
The Rotterdam Study is supported by theErasmus MC University Medical Center and Erasmus UniversityRotterdam; The Netherlands Organisation for Scientific Research(NWO); The Netherlands Organisation for Health Research andDevelopment (ZonMw); the Research Institute for Diseases in theElderly (RIDE); The Netherlands Genomics Initiative (NGI); theMinistry of Education, Culture and Science; the Ministry of Health,Welfare and Sports; the European Commission (DG XII); and theMunicipality of Rotterdam.
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Investigators Contacts
  • Dr. Prof M. Arfan Ikram
    Erasmus Medical Center


Study design
Population cohort
Follow Up
Baseline data collection was performed from October 1990 to July 1993. Since then all participants have been reexamined every 2-3 years. Morbidity and mortality is registered through general practitioners practises. Events are coded according to the International Classification for Primary Care (ICPC) and tenth edition of the International Classification of Disease (ICD) using clinical information obtained from the general practitioner and hospital discharge records. Examinations (bone mineral densiometry, including sample collections for in-depth molecular and genetic analyses) were repeated every 3-4 years in potentially changing characteristics. Participants were followed for the most common diseases in the elderly, including coronary heart disease, heart failure and stroke, Parkinson's disease, Alzheimer's disease and other dementias, depression and anxiety disorders, macular degeneration and glaucoma, diabetes mellitus and osteoporosis.

Marker Paper

Ikram MA, Brusselle GGO, Murad SD, van Duijn CM, Franco OH, Goedegebure A, Klaver CCW, Nijsten TEC, Peeters RP, Stricker BH, Tiemeier H, Uitterlinden AG, Vernooij MW, Hofman A. The Rotterdam Study: 2018 update on objectives, design and main results. Eur J Epidemiol. 2017 Sep;32(9):807-850. doi: 10.1007/s10654-017-0321-4. Epub 2017 Oct 24.

PUBMED 29064009


Sources of Recruitment
  • Individuals

Number of participants

Number of participants
Number of participants with biosamples
Supplementary Information
Aged 45 years or over


Availability of data and biosamples