Rotterdam Study
Initiatives
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The main objectives of the Rotterdam Study were to investigate the risk factors of cardiovascular, neurological, ophthalmological and endocrine diseases in the elderly.
- Start Year
- 1990
- Funding
- The Rotterdam Study is supported by theErasmus MC University Medical Center and Erasmus UniversityRotterdam; The Netherlands Organisation for Scientific Research(NWO); The Netherlands Organisation for Health Research andDevelopment (ZonMw); the Research Institute for Diseases in theElderly (RIDE); The Netherlands Genomics Initiative (NGI); theMinistry of Education, Culture and Science; the Ministry of Health,Welfare and Sports; the European Commission (DG XII); and theMunicipality of Rotterdam.
Visit RS
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Design
- Study design
- Population cohort
- Follow Up
- Baseline data collection was performed from October 1990 to July 1993. Since then all participants have been reexamined every 2-3 years. Morbidity and mortality is registered through general practitioners practises. Events are coded according to the International Classification for Primary Care (ICPC) and tenth edition of the International Classification of Disease (ICD) using clinical information obtained from the general practitioner and hospital discharge records. Examinations (bone mineral densiometry, including sample collections for in-depth molecular and genetic analyses) were repeated every 3-4 years in potentially changing characteristics. Participants were followed for the most common diseases in the elderly, including coronary heart disease, heart failure and stroke, Parkinson's disease, Alzheimer's disease and other dementias, depression and anxiety disorders, macular degeneration and glaucoma, diabetes mellitus and osteoporosis.
Marker Paper
Ikram MA, Brusselle GGO, Murad SD, van Duijn CM, Franco OH, Goedegebure A, Klaver CCW, Nijsten TEC, Peeters RP, Stricker BH, Tiemeier H, Uitterlinden AG, Vernooij MW, Hofman A. The Rotterdam Study: 2018 update on objectives, design and main results. Eur J Epidemiol. 2017 Sep;32(9):807-850. doi: 10.1007/s10654-017-0321-4. Epub 2017 Oct 24.
PUBMED 29064009
Recruitment
- Sources of Recruitment
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- Individuals
Number of participants
- Number of participants
- 14,926
- Number of participants with biosamples
- Supplementary Information
- Aged 45 years or over
Access
Availability of data and biosamples
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| Biosamples | |
| Other |