Individual Study / ROS

The Religious Orders Study

The Religious Orders Study

Initiatives -
The Religious Orders Study is a longitudinal clinical-pathologic cohort study of aging and Alzheimer’s disease (AD). It had two overall goals: One was to provide a source of brain tissue from well characterized comparable men and women with and without dementia for clinical-pathologic studies of aging and AD. The second was to obtain brain tissue from persons on whom risk factor information was obtained prior to the onset of dementia for studies linking risk factors to clinical and neuropathologic phenotypes. To accomplish these goals, the study enrolled participants without dementia and documented a wide range of potential risk factors for common chronic conditions of old age. *Note: All published information has been collected from the article referenced in the Marker Paper box below. Therefore, there may be variations with more advanced versions of the study.*


Investigators Contacts
  • Dr. Prof. David Bennett
    Rush University Medical Center


Study design
Patients' cohort

Marker Paper

Bennett DA, Schneider JA, Arvanitakis Z, et al. Overview and findings from the Religious Orders Study.Curr Alzheimer Res. 2012;9,628–645. doi:10.2174/156720512801322573

PUBMED 22471860


Sources of Recruitment
  • Individuals

Number of participants

Number of participants
Number of participants with biosamples


Availability of data and biosamples