Individual Study / RHEA

Mother-Child cohort in Crete

Mother-Child cohort in Crete

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Initiatives -
1. to characterize nutritional, environmental, and psychosocial determinants of children's growth and development; 2. to examine: * growth and physical development; * behavioral, cognitive, and sociο-emotional development; * allergies and asthma in childhood; * genotoxicity; 3. to evaluate mother’s health during and after pregnancy; 4. to evaluate genetic susceptibility for common disorders in childhood and the interactions between genetic and environmental factors affecting child health.
Start Year
End Year
European Union H2020 (LIFECYCLE), FP7 (HELIX, CHICOS, EnviroGenomarkers, ENRIECO, ESCAPE) and FP6 (HiWate, NewGeneris) programmes. The National Strategic Reference Framework (ESPA) 2007–13, the General Secretariat for Research and Technology in Greece and the Research Committee of the University of Crete, Greece.
Supplementary Information
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Investigators Contacts
  • Dr Leda Chatzi
    University of Crete
  • Dr Emmanouil Kogevinas
    Centre de Recerca en Epidemiologia Ambiental (CREAL)


Study design
Population cohort
Follow Up
At 8–10 weeks after giving birth, mothers were approached by phone. Subsequently, we completed in-person clinical visits with mothers and children during infancy (median ages 9 and 18 months), early childhood (median 4.2 years) and mid-childhood (median 6.5 years).
Supplementary Information

Marker Paper

Chatzi L, Leventakou V, Vafeiadi M, et al. Cohort Profile: The Mother-Child Cohort in Crete, Greece (Rhea Study). Int J Epidemiol. 2017;46(5):1392-1393k. doi:10.1093/ije/dyx084

PUBMED 29040580


Sources of Recruitment
  • Families
  • Other : Pregnant women and their newborns.

Number of participants

Number of participants
Number of participants with biosamples
Supplementary Information


Availability of data and biosamples


Availability of access information

On the study website :