Individual Study / REPRO_PL

Polish Mother and Child Cohort Study

Polish Mother and Child Cohort Study

Initiatives -
The aim of the study is to evaluate the impact of exposure to different environmental factors during pregnancy and after birth on pregnancy outcome and children's health. Specific research hypotheses refer to the role of heavy metals, exposure to polycyclic aromatic hydrocar-bons (PAHs) and environmental tobacco smoke (ETS) in the aetiology of intrauterine growth retardation (IUGR), preterm delivery (PD) and the risk of respiratory diseases, allergy and poor mental and physical development. It is also intended to explain the role of oxidative stress and nutritional status of the pregnant women. The impact of occupational exposures and stressful situations on pregnancy outcome will be evaluated from question-naire data.
Start Year
2007
End Year
2013
Funding
Polish Mother and Child Cohort Study is supported by three projects: 1. The project entitled: ""Epidemiology of reproductive hazards in Poland - multicentre, prospective cohort studies"" founded by the National Center for Research and Development, Poland (grant no. PBZ-MEiN-/8/2//2006; contract no. K140/P01/2007/1.3.1.1.) 2. The project entitled ""Prenatal and postnatal exposure to tobacco smoke, PAHs and heavy metals and the risk of respiratory diseases, allergy and poor mental and physical development"" supported by the grant PNRF-218-AI-1/07 from Norway through the Norwegian Financial Mechanism within the Polish-Norwegian Research Fund. The Project is carried out in the cooperation with The Norwegian Institute of Public Health. 3. The project entitled ""Phthalate exposure and birth outcome and child neurodevelopment"" supported by the DEC-2011/01/B/NZ7/06462 grant from the National Science Centre.
Supplementary Information
https://clinicaltrials.gov/ct2/show/NCT01861548
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Members

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Investigators Contacts
  • Dr. Wojciech Hanke
    Nofer Institute of Occupational Medicine
  • Dr. Kinga Polańska
    Nofer Institute of Occupational Medicine

Design

Study design
Population cohort
Follow Up
The follow-up of the women at 8-12, 20-24 and 30-34 weeks of pregnancy consists of the collection of biological samples and a questionnaire. Biological samples are collected during delivery and 2 more visits after delivery are conducted: within 1 and 6 weeks after delivery. The children are followed-up to the age of 2 years to determine long term effects of pre- and postnatal environmental exposures.

Marker Paper

Polańska K, Hanke W, Gromadzińska J, Ligocka D, Gulczyńska E, Sobala W, Wásowicz W. Polish mother and child cohort study--defining the problem, the aim of the study and methodological assumption. Int J Occup Med Environ Health. 2009;22(4):383-91. doi: 10.2478/v10001-009-0037-0.

PUBMED 20053622

Recruitment

Sources of Recruitment
  • Individuals

Number of participants

Number of participants
479
Number of participants with biosamples
Supplementary Information
Pregnant women

Access

Availability of data and biosamples

Data
Biosamples
Other