Individual Study / Pre- and postnatal exposure periods for child health: Common risks and shared mechanisms

Pre- and postnatal exposure periods for child health: Common risks and shared mechanisms

Pre- and postnatal exposure periods for child health: Common risks and shared mechanisms

Initiatives -
We especially target the prenatal period to examine if and how prenatal exposures may “program” adaptive biological responses in the fetus and child, with carry-forward effects on brain and somatic health; furthermore, we focus particularly on inflammation as a mediator of environmental exposures because it is a compelling biological mechanism by which a wide range of exposures may shape child neurodevelopment and obesity.
Start Year
2016
End Year
2023
Funding
National Institutes of Health
Visit Pre- and postnatal exposure periods for child health: Common risks and shared mechanisms

Members

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Investigators Contacts
  • Dr. Prof. Tomhas O'Connor
    University of Rochester Medical Center

Design

Study design
Population cohort
Follow Up
The 500 children will be extensively studied at newborn, 6 months, 1 year, 2 years, 3 years, and 4 years of age.

Marker Paper

Rasmussen JM, Graham AM, Entringer S, Gilmore JH, Styner M, Fair DA, Wadhwa PD, Buss C. Maternal Interleukin-6 concentration during pregnancy is associated with variation in frontolimbic white matter and cognitive development in early life. Neuroimage. 2019 Jan 15;185:825-835. doi: 10.1016/j.neuroimage.2018.04.020. Epub 2018 Apr 11.

PUBMED 29654875

Recruitment

Sources of Recruitment
  • Families

Number of participants

Number of participants
500
Number of participants with biosamples

Access

Availability of data and biosamples

Data
Biosamples
Other