Physicians' Health Study II
Initiatives
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To test four of the most popular and promising agents--vitamin C, vitamin E, beta-carotene, and a multivitamin--for the primary prevention of cardiovascular disease, total cancer, and prostate cancer. To evaluate the effect of these agents on colon polyps and colon cancer, cataract, macular degeneration, and early cognitive decline.
**General contact: phs@rics.bwh.harvard.edu**
- Start Year
- 1997
- End Year
- 2007
- Funding
- PHS-II is funded by the National Institutes of Health and several industry sponsors.
Visit PHS-II
| Investigators | Contacts |
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Design
- Study design
- Clinical trial cohort
- Follow Up
- Once a year, PHS-II participants get a 12-month supply of study pills in calendar packs. This shipment also contains an annual follow-up questionnaire. It includes questions about compliance with the study treatments, use of non-study medications, occurrence of major illnesses or adverse effects, and other risk factor information.
Marker Paper
Christen WG, Gaziano JM, Hennekens CH. Design of Physicians' Health Study II--a randomized trial of beta-carotene, vitamins E and C, and multivitamins, in prevention of cancer, cardiovascular disease, and eye disease, and review of results of completed trials. Ann Epidemiol. 2000 Feb;10(2):125-34. doi: 10.1016/s1047-2797(99)00042-3.
PUBMED 10691066
Recruitment
- Sources of Recruitment
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- Individuals
Number of participants
- Number of participants
- 14,641
- Number of participants with biosamples
- Supplementary Information
- male physicians aged 50 years and older who were registered with the American Medical Association and who had not taken part in PHS I.
Access
Availability of data and biosamples
| Data | |
| Biosamples | |
| Other |