Individual Study / PHS-I

Physicians' Health Study I

Physicians' Health Study I

PHS-I logo
Initiatives -
To test the benefits and risks of aspirin and beta carotene in the primary prevention of cardiovascular disease and cancer. **General contact: **
Start Year
End Year
The Physicians' Health Study-I was supported by four grants from the National Institutes of Health: CA-34944 and CA-40360 from the National Cancer Institute, and HL-26490 and HL-34595 from the National Heart, Lung, and Blood Institute.
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Investigators Contacts
  • Dr Julie E. Buring
    Harvard T.H. Chan School of Public Health
  • MD J.Michael Gaziano
    VA CSP Massachusetts Veteran’s Epidemiology Research Center (MAVERIC)


Study design
Clinical trial cohort
Follow Up
The first follow-up questionnaires were sent at six and 12 months of treatment. After that, questionnaires were sent yearly. They included questions about compliance with the study treatments, use of non-study medications, occurrence of major illnesses or adverse effects, and other risk factor information.

Marker Paper

Steering Committee of the Physicians' Health Study Research Group. Preliminary report: Findings from the aspirin component of the ongoing Physicians' Health Study. N Engl J Med. 1988 Jan 28;318(4):262-4. doi: 10.1056/NEJM198801283180431.

PUBMED 3275899


Sources of Recruitment
  • Individuals

Number of participants

Number of participants
Number of participants with biosamples
Supplementary Information
Male physicians between 40 and 84 years of age who lived in the United States and who were registered with the American Medical Association.


Availability of data and biosamples