Individual Study / NTR

Netherlands Twin Registry

Netherlands Twin Registry

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Initiatives -
Studies that include items about health, fertility, lifestyle, addiction, personality and psychopathology, religion, socioeconomic status, and educational attainment. Investigates the role of hereditary predisposition and environmental factors on individual differences in mental and physical health.
Start Year
1986
End Year
2001
Funding
Funding was obtained from the Netherlands Organization for Scientific Research (NWO) and The Netherlands Organisation for Health Research and Development (ZonMW) grants 904-61-090, 985-10-002, 912-10-020, 904-61-193,480-04-004, 463-06-001, 451-04-034, 400-05-717,Addiction-31160008, 016-115-035, 481-08-011, 056-32-010, Middelgroot-911-09-032, OCW_NWO Gravity program-024.001.003, NWO-Groot 480-15-001/674, NWO Veni 451-15-017, Center for Medical Systems Biology(CSMB, NWO Genomics), NBIC/BioAssist/RK(2008.024), Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL, 184.021.007and 184.033.111); Spinozapremie (NWO-56-464-14192), KNAW Academy Professor Award (PAH/6635) and University Research Fellow grant (URF)to DIB; Amsterdam Public Health research institute (former EMGOþ),Neuroscience Amsterdam research institute (former NCA); the European Science Foundation (ESF, EU/QLRT-2001-01254), the European Community’s Seventh Framework Program (FP7-HEALTH-F4-2007-2013,grant 01413: ENGAGE and grant 602768: ACTION); the European Research Council (ERC Starting 284167, ERC Consolidator 771057, ERC Advanced 230374), Rutgers University Cell and DNA Repository (NIMH U24MH068457-06), the National Institutes of Health (NIH, R01D0042157-01A1,R01MH58799-03, MH081802, DA018673, R01 DK092127-04, Grand Opportunity grants 1RC2 MH089951 and 1RC2 MH089995); the Avera Institute for Human Genetics, Sioux Falls, South Dakota (USA). Part of the genotyping and analyses were funded by the Genetic Association Information Network (GAIN) of the Foundation for the National Institutes of Health. Computing was supported by NWO through grant 2018/EW/00408559, BiG Grid, the Dutch e-Science Grid and SURFSARA.
Supplementary Information
https://www.rug.nl/research/portal/en/publications/netherlands-twin-register(b0e8f46b-7b07-4cfc-8914-2f0fb2076a6e).html
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Members

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Investigators Contacts
  • Dr Lannie Lighart
    Vrije Universiteit Amsterdam
  • Dr. Professor Dorret Boomsma
    Vrije Universiteit Amsterdam
  • Dr. Professor Meike Bartels
    Vrije Universiteit Amsterdam

Design

Study design
Population cohort
Follow Up
Questionnaires are mailed to parents of twins at ages 0, 2, 3, 5, 7, 10 and 12 years. At ages 7, 9/10 and 12 years, we also ask parents for permission to approach the twins’ teachers. At that same moment, we ask if there are any additional siblings in the family who are in elementary school and whose teachers may be approached. From age 14 onward, adolescent twins and their siblings are invited to provide self-reports (after their parents give permission), largely substituting parental for self-report form this age onward. Once they become adults, the Young NTR (YNTR) twins can opt to join the Adult NTR (ANTR).

Marker Paper

Ligthart, L., van Beijsterveldt, C. E. M., Kevenaar, S. T., de Zeeuw, E. L., van Bergen, E., Bruins, S., ... Boomsma, D. I. (2019). The Netherlands Twin Register: Longitudinal Research Based on Twin and Twin-Family Designs. Twin research and human genetics : the official journal of the International Society for Twin Studies, 22(6), 623-636. https://doi.org/10.1017/thg.2019.93

PUBMED 31666148

Recruitment

Sources of Recruitment
  • Individuals
  • Families

Number of participants

Number of participants
60,000
Number of participants with biosamples
Supplementary Information
Twins, multiples and their parents, siblings, spouses and other family members.

Access

Availability of data and biosamples

Data
Biosamples
Other

Availability of access information

On the study website : https://tweelingenregister.vu.nl/