Nutrition Intervention Trials — Linxian
Initiatives
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The main objective until 1991 was to test the effects of multiple vitamin and mineral interventions on total mortality and total and cause-specific cancer mortality in a rural Chinese population. The objectives of the follow-up study are:
1. to continue to determine cancer incidence and all causes of mortality in trial participants after intervention to permit examination of potential effects of the interventions on total and cause-specific mortality and cancer incidence in the post-intervention period;
2. to conduct a cross-sectional nutritional survey in a subsample of living trial participants to evaluate their nutritional status, asses the validity of dietary questionnaires, and relate neurologic status to vitamin B12 plasma levels;
3. to collect a blood sample from all living trial participants to permit further etiologic investigations of genetic and environmental hypotheses;
4. to perform nested case-control studies of selected genetic and environmental hypotheses.
- Start Year
- 1985
- Funding
- National Cancer Institute
Visit NIT
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Design
- Study design
- Clinical trial cohort
- Follow Up
- In the subsequent 10 years post trial, village health workers or study interviewers continued to contact participants monthly. For new cancer diagnoses and deaths, diagnostic materials were collected and cancer diagnoses were verified by the panel of American and Chinese experts (1991 to 1996) or senior Chinese diagnosticians from Beijing (1996–2001)
Marker Paper
Li B, Taylor PR, Li JY, Dawsey SM, Wang W, Tangrea JA, Liu BQ, Ershow AG, Zheng SF, Fraumeni JF Jr, et al. Linxian nutrition intervention trials. Design, methods, participant characteristics, and compliance. Ann Epidemiol. 1993 Nov;3(6):577-85. doi: 10.1016/1047-2797(93)90078-i.
PUBMED 7921303
Recruitment
- Sources of Recruitment
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- Individuals
Number of participants
- Number of participants
- 32,887
- Number of participants with biosamples
Access
Availability of data and biosamples
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| Biosamples | |
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