Individual Study / NHBCS

New Hampshire Birth Cohort Study (NHBCS)

New Hampshire Birth Cohort Study (NHBCS)

NHBCS logo
Initiatives -
1. Leveraging the extant NHBCS to perform targeted and unsupervised metabolomic analyses of 1,000 cord blood samples and 250 paired maternal gestational blood samples, and assess associations with exposures, early growth, and the infant microbiome; 2. expanding data acquisition, sample collection and participant accrual to more precisely characterize exposures and timing of early life exposures by obtaining urinary metallome and metal metabolomic measurements, and exposome monitoring data from the first trimester of pregnancy, along with spatial analysis of naturally shed teeth for prenatal metal concentrations; 3. extending follow-up to identify childhood exposures to contaminants (through biomarkers and personal monitors); the home environment (e.g., physical activity and sleep patterns, food environment, green, blue and white space, and media usage); and medical exposures (e.g., prescription and non-prescription medications and surgical interventions) that relate to fetal and childhood growth, obesity at age 3 years, respiratory infection and asthma by age 5 years, and pulmonary function data at age 7.5 years.
Start Year
National Institutes of Health (NIH)


Investigators Contacts
  • Dr. Margaret Rita Karagas
    Center for Molecular Epidemiology at Dartmouth University of Washington


Study design
Population cohort


Sources of Recruitment
  • Families

Number of participants

Number of participants
Number of participants with biosamples
Supplementary Information
The study has recruited over 2,500 mother-infant pairs (over 4,000 individuals)


Availability of data and biosamples