Individual Study / MSS-II

Mild Stroke Study II

Mild Stroke Study II

Initiatives -
To determine the tracer kinetic modelling approach most suitable for assessing subtle BBB leakage using a data-driven approach, to determine its validity both in theory and experimentally and to obtain tracer kinetic parameters for normal-appearing tissues and lesions. *Note: All published information has been collected from the article referenced in the Marker Paper box below. Therefore, there may be variations with more advanced versions of the study.*
Start Year
2010
End Year
2015
Funding
This work was funded by Wellcome Trust (SDM, recruitment and MRI scanning costs; grant 088134/Z/09/A), Row Fogo Charitable Trust (MCVH, AKH), Age UK (SMM), NHS Lothian Research and Development Office (MJT), Scottish Funding Council and the Chief Scientist Office of Scotland for funding the Scottish Imaging Network: A Platform for Scientific Excellence (“SINAPSE”; JMW, radiography staff).

Members

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Investigators Contacts
  • Dr. Prof. Joanna Wardlaw
    University of Edinburgh

Design

Study design
Patients' cohort
Follow Up
Baseline ( < 2 weeks of stroke)- follow ups at 1-3 months and 1 year.

Marker Paper

Heye, A. K., Thrippleton, M. J., Armitage, P. A., Valdés Hernández, M., Makin, S. D., Glatz, A., Sakka, E., & Wardlaw, J. M. (2016). Tracer kinetic modelling for DCE-MRI quantification of subtle blood-brain barrier permeability. NeuroImage, 125, 446–455. https://doi.org/10.1016/j.neuroimage.2015.10.018

Recruitment

Sources of Recruitment
  • Individuals

Number of participants

Number of participants
264
Number of participants with biosamples
Supplementary Information
Aged 30-90 years of age

Access

Availability of data and biosamples

Data
Biosamples
Other