Individual Study / CFAS

Cognitive Function and Ageing Study (CFAS)

Cognitive Function and Ageing Study (CFAS)

CFAS logo
Initiatives -
The initial aims of MRC CFAS were: 1. To find out how common dementia and associated conditions are in England and Wales (prevalence) and also, how many new cases of dementia develop each year (incidence); 2. To find out if dementia varies around the country; 3. To describe the service needs of dementia sufferers and the degree of disability suffered; 4. To explore which factors increase the risk of someone developing dementia; 5. To investigate the different diseases that cause dementia and how quickly dementia progresses.
Start Year
End Year
The Medical Research Council (G990140) and the Health Department.
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Investigators Contacts
  • Prof. Tom Dening
    University of Nottingham
  • Dr. Blossom Stephan
    Newcastle University
  • Prof. Carol Brayne
    University of Cambridg


Study design
Population cohort
Follow Up
The follow-up consisted of an assessment (designed to be conducted 1 month after the screening interview) and annual interview (designed to be conducted 1 year after the screening interview). At the assessment and biannual follow-up interview permission was sought to approach and interview a relative or carer to ask for an objective account of the respondent’s health and abilities. Six years after the initial screening interview, all respondents in the assessed groups were interviewed. At 8 years only those who had indicated an intention to donate brain tissue were re-interviewed. At 10 years all survivors from the responding group of the complete study were re-contacted for interview.

Marker Paper

Minett, T., Classey, J., Matthews, F. E., Fahrenhold, M., Taga, M., Brayne, C., Ince, P. G., Nicoll, J. A., Boche, D., & MRC CFAS (2016). Microglial immunophenotype in dementia with Alzheimer's pathology. Journal of neuroinflammation, 13(1), 135.

PUBMED 16980700


Sources of Recruitment
  • Individuals

Number of participants

Number of participants
Number of participants with biosamples


Availability of data and biosamples


Availability of access information

On the study website :