Individual Study / MESA

Multi-Ethnic Study of Atherosclerosis

Multi-Ethnic Study of Atherosclerosis

MESA logo
Initiatives -
The objectives of MESA are: 1. To determine characteristics related to progression of subclinical cardiovascular disease (CVD) to clinical CVD; 2. To determine characteristics related to progression of subclinical CVD itself; 3. To assess ethnic, age, and sex differences in subclinical disease prevalence, risk of progression, and rates of clinical CVD; 4. To determine relations of newly identified factors with subclinical disease and to determine their incremental predictive value over established risk factors; 5. To develop methods, suitable for application in future screening and intervention studies, for characterizing risk among asymptomatic persons.
Start Year
End Year
This research is supported by contracts N01-HC-95159 through N01-HC-95169 with the National Heart, Lung, and Blood Institute.
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Investigators Contacts
  • Dr Craig Johnson
    University of Washinton
  • Lorraine Silsbee
    National Institutes of Health


Study design
Population cohort
Follow Up
For classification of CVD events occurring during follow-up in MESA, information will be collected from death certificates, medical records from hospitalizations, autopsy reports, interviews with participants, and, in the case of out-of-hospital deaths, interviews with or questionnaires administered to physicians, relatives, or friends. MESA Assay Census for Exams 1-6( 2002,2004,2005,2007,2011 and 2018)

Marker Paper

Bild DE, Bluemke DA, Burke GL, Detrano R, Diez Roux AV, Folsom AR, Greenland P, Jacob DR Jr, Kronmal R, Liu K, Nelson JC, O'Leary D, Saad MF, Shea S, Szklo M, Tracy RP. Multi-Ethnic Study of Atherosclerosis: objectives and design. Am J Epidemiol. 2002 Nov 1;156(9):871-81. doi: 10.1093/aje/kwf113.

PUBMED 12397006


Sources of Recruitment
  • Individuals

Number of participants

Number of participants
Number of participants with biosamples
Supplementary Information
Asymptomatic men and women aged 45-84. Approximately 38 percent of the recruited participants are white, 28 percent African-American, 22 percent Hispanic, and 12 percent Asian, predominantly of Chinese descent.


Availability of data and biosamples


Availability of access information

On the study website :