Individual Study / LSS

Life Span Study Cohort

Life Span Study Cohort

Initiatives -
To investigate the long-term effects of A-bomb radiation on causes of death and incidence of cancer.To ascertain whether those who escaped death from the acute effects of the bombs continue to survive as long as the nonexposed, and whether any diminution in their life expectation is a function of apparent radiation dosage.
Start Year
1958
Funding
Japanese Ministry of Health, Labour and Welfare (MHLW) and the U.S. Department of Energy (DOE). The research was also funded in part through DOE award DE-HS0000031 to the National Academy of Sciences.
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Members

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Investigators Contacts
  • MD. Dr Kotaro Ozasa
    Radiation Effects Research Foundation

Design

Study design
Population cohort
Follow Up
Follow-up since 1950. Mortality information is secured by utilizing the regular Japanese reporting systems under special arrangements concluded for this study by the Ministry of Health and Welfare with which the study is jointly conducted. Primary notice of death is obtained by consulting family registers, while detail, including the attending physician’s statement of cause of death, is obtained from the Vital Statistics Death Schedule, an abstract of the death certificate which, in Japan, serves as the basis for mortality analysis on a national level. A subsample of 24358 subjects were invited to the biennial health examination program called the Adult Health Study (AHS) at ABCC clinics in Hiroshima and Nagasaki since 1958.

Marker Paper

Ozasa K, Grant EJ, Kodama K. Japanese Legacy Cohorts: The Life Span Study Atomic Bomb Survivor Cohort and Survivors' Offspring. J Epidemiol. 2018 Apr 5;28(4):162-169. doi: 10.2188/jea.JE20170321. Epub 2018 Mar 17. PMID: 29553058; PMCID: PMC5865006.

PUBMED 29553058

Recruitment

Sources of Recruitment
  • Individuals

Number of participants

Number of participants
120,321
Number of participants with biosamples
Supplementary Information
Residents of Hiroshima and Nagasaki identified through the national census in 1950 have been followed since that time- Atomic bomb survivors

Access

Availability of data and biosamples

Data
Biosamples
Other