Individual Study / LRC

Princeton Lipid Research Study

Princeton Lipid Research Study

Initiatives -
To describe lipid level distributions in free-living populations and their associations with other cardiovascular disease (CVD) risk factors. The follow-up study aim was to assess 30-year changes in the familial associations of CVD risk factors. *Note: All published information has been collected from the article referenced in the Marker Paper box below. Therefore, there may be variations with more advanced versions of the study.*
Start Year
National Heart, Lung, and Blood Institute LRC contract NO1-HV22914-L and research grant R01-HL162394 and American Heart Association grant 9750129N.


Investigators Contacts
  • Dr Lisa Aronson Friedman
    Maryland Medical Research Institute


Follow Up
Baseline Visit 2 examination 6 weeks later where major CVD risk factors were obtained; an additional 557 children (siblings of LRC participants) attended a family-based study 18 months later (Visit 3), where lipids and anthropometry, but not blood pressure, were obtained. Between 1999 and 2004, the Princeton Follow-up Study (PFS) followed up elegible participants in adulthood. PFS was a 25–30-year follow-up of these student and parent-participants to prospectively assess changes in CVD risk factors from childhood into the 4th–5th decades of life.

Marker Paper

Friedman LA, Morrison JA, Daniels SR, McCarthy WF, Sprecher DL. Sensitivity and specificity of pediatric lipid determinations for adult lipid status: findings from the Princeton Lipid Research Clinics Prevalence Program Follow-up Study. Pediatrics. 2006 Jul;118(1):165-72. doi: 10.1542/peds.2005-2968.

PUBMED 16818562


Sources of Recruitment
  • Families

Number of participants

Number of participants
Number of participants with biosamples


Availability of data and biosamples