Individual Study / LifeLines

LifeLines Cohort Study & Biobank

LifeLines Cohort Study & Biobank

LifeLines logo
Initiatives -
Research on complex interactions between environmental, phenotypic and genomic factors in the development of chronic diseases and healthy ageing. To gain insight into the aetiology of healthy ageing. Further understanding of why, for instance, some people with overweight develop diabetes, some develop cardiovascular disorders and others remain free of disease will enable us to move forward to more personalized preventionand personalized medicine, ultimately resulting in adding additional years of healthy life. ****
Start Year
End Year
LifeLines has been funded by a number of public sources, notably the Dutch Government, The Netherlands Organization of Scientific Research NWO, the Northern Netherlands Collaboration of Provinces (SNN), the European fund for regional development, Dutch Ministry of Economic Affairs, Pieken in de Delta, Provinces of Groningen and Drenthe, the Target project, BBMRI-NL, theUniversity of Groningen, and the University Medical Center Groningen, The Netherlands.
Supplementary Information
Visit LifeLines


Investigators Contacts
  • Dr. Salome Scholtens
    University Medical Center Groningen (UMCG)
  • Dr. Ronald Stolk
    University Medical Center Groningen (UMCG)


Study design
Population cohort
Follow Up
Followed-up for at least 30 years-participants are invited to complete follow-up questionnaires approximately once every 1.5 years. Once every 5 years participants visit a Lifelines location where biological samples are collected and several measurements and tests are conducted.
Supplementary Information

Marker Paper

Stolk RP, Rosmalen JG, Postma DS, de Boer RA, Navis G, Slaets JP, Ormel J, Wolffenbuttel BHR. Universal risk factors for multifactorial diseases: LifeLines: a three-generation population-based study. Eur J Epidemiol 2008; 23(1): 67-74.

PUBMED 18075776


Sources of Recruitment
  • Individuals
  • Families

Number of participants

Number of participants
Number of participants with biosamples
Supplementary Information
Northern population of the Netherlands. The Lifelines cohort distinguishes three generations: a children's cohort (aged 0-18 years at baseline), an adult cohort (18 years – 65 years at baseline) and an elderly cohort (+65 years at baseline).


Availability of data and biosamples


Availability of access information

On the study website :

By contacting the study representative