Individual Study / LA DREAMERS

Lifecourse Approach to developmental repercussions of environmental agents on metabolic and respiratory health (LA DREAMERS)

Lifecourse Approach to developmental repercussions of environmental agents on metabolic and respiratory health (LA DREAMERS)

Initiatives -
The proposed study addresses the following key questions in the field: 1. Do prenatal and early childhood environmental exposures alter childhood and emergent adult respiratory and metabolic health? If so, are there critical periods of exposure across the lifecourse? 2. What is the role of altered immune functions in the underlying biological mechanisms? 3. Will more precise exposure assessment for ambient air pollutants through application of a national spatiotemporal model or development of biomarkers in neonatal dried blood spots and cord blood allow critical components of the mixture to be identified? 4. Do prenatal environmental exposures induce transgenerational epigenetic alterations that help explain increased risk of disease? 5. Can innovative statistical approaches untangle the effects of exposure mixtures on multiple health outcomes? 
Start Year
2016
End Year
2023
Funding
National Institutes of Health (NIH)
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Members

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Investigators Contacts
  • MD. PhD. Prof. Frank D Gilliland
    Keck School of Medicine of USC

Design

Study design
Population cohort

Marker Paper

Farzan SF, Howe CG, Chavez TA, Hodes TL, Johnston JE, Habre R, Dunton G, Bastain TM, Breton CV. Demographic predictors of urinary arsenic in a low-income predominantly Hispanic pregnancy cohort in Los Angeles. J Expo Sci Environ Epidemiol. 2021 Feb;31(1):94-107. doi: 10.1038/s41370-020-0251-1. Epub 2020 Jul 27.

PUBMED 32719440

Recruitment

Sources of Recruitment
  • Individuals

Number of participants

Number of participants
8,931
Number of participants with biosamples

Access

Availability of data and biosamples

Data
Biosamples
Other