Structural plasticity of the hippocampus and amygdala induced by Electroconvulsive Therapy in major depression (The GEMRIC LosAngeles, CA, USA center)
Initiatives
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Electroconvulsive therapy (ECT) elicits a rapid and robust clinical response in patients with refractory depression. Neuroimaging measurements of structural plasticity relating to and predictive of ECT response may point to the mechanisms underlying rapid antidepressant effects and establish biomarkers to inform other treatments. In this study, the researchers determined the effects of diagnosis and of ECT on global and local variations of hippocampal and amygdala structures in major depression and predictors of ECT-related clinical response.
Visit Joshi_Biol Psychiatry_2016
| Investigators | Contacts |
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Design
- Study design
- Patients' cohort
Marker Paper
Joshi SH, Espinoza RT, Pirnia T, et al. Structural plasticity of the hippocampus and amygdala induced by electroconvulsive therapy in major depression. Biol Psychiatry. 2016;79(4):282–292. doi:10.1016/j.biopsych.2015.02.029
PUBMED 25842202
Recruitment
- Sources of Recruitment
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- Individuals
Number of participants
- Number of participants
- 43
- Number of participants with biosamples
- Supplementary Information
- This site was still including patient at the moment of the inclusion in the initiative.
Access
Availability of data and biosamples
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Availability of access information
On the study website : https://mmiv.no/gemric/