Individual Study / Joshi_Biol Psychiatry_2016

Structural plasticity of the hippocampus and amygdala induced by Electroconvulsive Therapy in major depression (The GEMRIC LosAngeles, CA, USA center)

Structural plasticity of the hippocampus and amygdala induced by Electroconvulsive Therapy in major depression (The GEMRIC LosAngeles, CA, USA center)

Initiatives -
Electroconvulsive therapy (ECT) elicits a rapid and robust clinical response in patients with refractory depression. Neuroimaging measurements of structural plasticity relating to and predictive of ECT response may point to the mechanisms underlying rapid antidepressant effects and establish biomarkers to inform other treatments. In this study, the researchers determined the effects of diagnosis and of ECT on global and local variations of hippocampal and amygdala structures in major depression and predictors of ECT-related clinical response.
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Members

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Investigators Contacts
  • Dr. Katherine Narr
    University of California at Los Angeles

Design

Study design
Patients' cohort

Marker Paper

Joshi SH, Espinoza RT, Pirnia T, et al. Structural plasticity of the hippocampus and amygdala induced by electroconvulsive therapy in major depression. Biol Psychiatry. 2016;79(4):282–292. doi:10.1016/j.biopsych.2015.02.029

PUBMED 25842202

Recruitment

Sources of Recruitment
  • Individuals

Number of participants

Number of participants
43
Number of participants with biosamples
Supplementary Information
This site was still including patient at the moment of the inclusion in the initiative.

Access

Availability of data and biosamples

Data
Biosamples
Other

Availability of access information

On the study website : https://mmiv.no/gemric/