THE IMPACT OF THE INTRAUTERINE AND EARLY CHILDHOOD ENVIRONMENTS ON NEUROCOGNITIVE AND METABOLIC DEVELOPMENT IN AFRICAN AMERICAN YOUTH: FOCUS ON THE GUT-BRAIN AXIS
Initiatives
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Through ECHO, we propose to elucidate exposures and risk pathways that contribute to neurodevelopmental deficits and obesity in preschool aged AA children by:
1. Assembling an Atlanta ECHO cohort of ~440 AA socioeconomically diverse mother-child pairs by combining extant cohorts for whom the prenatal, perinatal, and early childhood environments are, or will be, characterized;
2. Completing the analysis and synthesis of data from the Atlanta ECHO cohort to characterize mother-child pairs in terms of prenatal and early childhood exposures (toxicants, stressors and neuroendocrine-immune activation, nutritional and metabolic status, microbiome and infections, bonding and interaction); epigenetic and metabolomic profiles; and perinatal outcomes (gestational age, size-for-gestation);
3. Testing cohort-specific hypotheses related to prenatal and early childhood exposures and neurodevelopmental outcomes and obesity in AA children at 2, 3, 4, and 5 years of age;
4. Participating in ECHO-wide consortium studies to identify risk and protective factors that moderate associations between environmental exposures, typical growth and development, and adverse child health outcomes
- Start Year
- 2016
- End Year
- 2018
- Funding
- National Institute of Child Health and Development (NICHD)
Visit INTRAUTERINE AND EARLY CHILDHOOD ENVIRONMENTS ON NEUROCOGNITIVE . gut-brain axis
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Design
- Study design
- Population cohort
- Follow Up
- Subjects provided a venous blood sample during early (6-15 weeks) and late (22-33 weeks) pregnancy.
Marker Paper
Knight AK, Dunlop AL, Kilaru V, Cobb D, Corwin EJ, Conneely KN, Smith AK. Characterization of gene expression changes over healthy term pregnancies. PLoS One. 2018 Oct 10;13(10):e0204228. doi: 10.1371/journal.pone.0204228.
PUBMED 30303981
Recruitment
- Sources of Recruitment
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- Families
Number of participants
- Number of participants
- 440
- Number of participants with biosamples
Access
Availability of data and biosamples
| Data | |
| Biosamples | |
| Other |