Individual Study / INTRAUTERINE AND EARLY CHILDHOOD ENVIRONMENTS ON NEUROCOGNITIVE . gut-brain axis

THE IMPACT OF THE INTRAUTERINE AND EARLY CHILDHOOD ENVIRONMENTS ON NEUROCOGNITIVE AND METABOLIC DEVELOPMENT IN AFRICAN AMERICAN YOUTH: FOCUS ON THE GUT-BRAIN AXIS

THE IMPACT OF THE INTRAUTERINE AND EARLY CHILDHOOD ENVIRONMENTS ON NEUROCOGNITIVE AND METABOLIC DEVELOPMENT IN AFRICAN AMERICAN YOUTH: FOCUS ON THE GUT-BRAIN AXIS

Initiatives -
Through ECHO, we propose to elucidate exposures and risk pathways that contribute to neurodevelopmental deficits and obesity in preschool aged AA children by: 1. Assembling an Atlanta ECHO cohort of ~440 AA socioeconomically diverse mother-child pairs by combining extant cohorts for whom the prenatal, perinatal, and early childhood environments are, or will be, characterized; 2. Completing the analysis and synthesis of data from the Atlanta ECHO cohort to characterize mother-child pairs in terms of prenatal and early childhood exposures (toxicants, stressors and neuroendocrine-immune activation, nutritional and metabolic status, microbiome and infections, bonding and interaction); epigenetic and metabolomic profiles; and perinatal outcomes (gestational age, size-for-gestation); 3. Testing cohort-specific hypotheses related to prenatal and early childhood exposures and neurodevelopmental outcomes and obesity in AA children at 2, 3, 4, and 5 years of age; 4. Participating in ECHO-wide consortium studies to identify risk and protective factors that moderate associations between environmental exposures, typical growth and development, and adverse child health outcomes
Start Year
2016
End Year
2018
Funding
National Institute of Child Health and Development (NICHD)
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Members

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Investigators Contacts
  • MD. Anne Lang Dunlop
    Nell Hodgson Woodruff School of Nursing, Emory University

Design

Study design
Population cohort
Follow Up
Subjects provided a venous blood sample during early (6-15 weeks) and late (22-33 weeks) pregnancy.

Marker Paper

Knight AK, Dunlop AL, Kilaru V, Cobb D, Corwin EJ, Conneely KN, Smith AK. Characterization of gene expression changes over healthy term pregnancies. PLoS One. 2018 Oct 10;13(10):e0204228. doi: 10.1371/journal.pone.0204228.

PUBMED 30303981

Recruitment

Sources of Recruitment
  • Families

Number of participants

Number of participants
440
Number of participants with biosamples

Access

Availability of data and biosamples

Data
Biosamples
Other