Individual Study / InterAct



Initiatives -
* Set up a nested case-cohort study for the analysis of gene-lifestyle interaction in observational studies of diabetes incidence. * Analysis of nutritional factors and physical activity to study the association of nutritional, dietary and physical activity behaviours with incident diabetes in the nested case-cohort study and to contribute to the analysis of gene-lifestyle interaction. * Analysis of genetic factors to study the association of genetic variation with incident diabetes in the nested case-cohort study and to contribute to the analysis of main genetic effects and gene-lifestyle interaction. * Analysis of gene-lifestyle interaction to construct a consortium of lifestyle intervention diabetes prevention trials in order to study the association of the genetic variation with differential response to the lifestyle intervention and to consider the implications of these findings for preventive action.
Start Year
European Union (Integrated Project LSHM-CT-2006-037197 in the Framework Programme 6 of the European Community)
Visit InterAct


Investigators Contacts
  • Dr. Nick Wareham
    University of Cambrige
  • Dr. Claudia Langenberg
    University of Cambrige
  • Project secretariat Meriel Smith
    University of Cambrige


Study design
Other : Case-cohort
Follow Up
Follow-up data on mortality and disease status has been ascertained via registries, clinical records, and other sources of clinical information. At least one follow-up was conducted in each centre 3-5 years after baseline and questionnaires and telephone-based interviews were administered to repeat exposure measurement and collect self-reported health status data.

Marker Paper

InterAct Consortium, Langenberg C, Sharp S, Forouhi NG, Franks PW, Schulze MB, Kerrison N, Ekelund U, Barroso I, Panico S, Tormo MJ, Spranger J, Griffin S, van der Schouw YT, Amiano P, Ardanaz E, Arriola L, Balkau B, Barricarte A, Beulens JW, Boeing H, Bueno-de-Mesquita HB, Buijsse B, Chirlaque Lopez MD, Clavel-Chapelon F, Crowe FL, de Lauzon-Guillan B, Deloukas P, Dorronsoro M, Drogan D, Froguel P, Gonzalez C, Grioni S, Groop L, Groves C, Hainaut P, Halkjaer J, Hallmans G, Hansen T, Huerta Castaño JM, Kaaks R, Key TJ, Khaw KT, Koulman A, Mattiello A, Navarro C, Nilsson P, Norat T, Overvad K, Palla L, Palli D, Pedersen O, Peeters PH, Quirós JR, Ramachandran A, Rodriguez-Suarez L, Rolandsson O, Romaguera D, Romieu I, Sacerdote C, Sánchez MJ, Sandbaek A, Slimani N, Sluijs I, Spijkerman AM, Teucher B, Tjonneland A, Tumino R, van der A DL, Verschuren WM, Tuomilehto J, Feskens E, McCarthy M, Riboli E, Wareham NJ. Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study. Diabetologia. 2011 Sep;54(9):2272-82. doi: 10.1007/s00125-011-2182-9. Epub 2011 Jun 30.

PUBMED 21717116

Number of participants

Number of participants
Number of participants with biosamples


Availability of data and biosamples