Individual Study / InCHIANTI

The Invecchiare in Chianti study (InCHIANTI)

The Invecchiare in Chianti study (InCHIANTI)

Initiatives -
The main goal is to translate epidemiological research into geriatric clinical tools that makes possible more precise diagnosis and more effective treatment in older persons with mobility problems. In particular, the plan is: 1. study how the various physiological subsystems that are important for mobility interact with age in causing disability; 2. develop reference values for the integrity and functionality of the different physiologic subsystems that are implicated in mobility, to be used in clinical practice; 3. look at risk factors for the development of “soft” neurological impairments in the absence of neurological disease that is already clinically evident; 4. identify biomarkers of disregulation of the biological network of signals that maintain a stable homeostasis equilibrium after a distressful event, such as a disease or injury; 5. scientific evidence relevant to public health, prevention and intervention trials. ****
Start Year
End Year
Italian Health Ministry and by a NIH contract.


Study design
Population cohort
Follow Up
Baseline (1997). Participants were followed up for over 15 years, the follow ups were conducted in 2002, 2004-2006, 2008 and 2013-2015.

Marker Paper

Cesari M, Pahor M, Bartali B, et al. Antioxidants and physical performance in elderly persons: the Invecchiare in Chianti (InCHIANTI) study [published correction appears in Am J Clin Nutr. 2004 Jul;80(1):238]. Am J Clin Nutr. 2004;79(2):289-294. doi:10.1093/ajcn/79.2.289

PUBMED 14749236


Sources of Recruitment
  • Individuals

Number of participants

Number of participants
Number of participants with biosamples
Supplementary Information
Over 65 years old


Availability of data and biosamples


Availability of access information

On the study website :