Individual Study / Guanacaste Project

Guanacaste HPV Natural History Study

Guanacaste HPV Natural History Study

Initiatives -
To investigate the role of human papillomavirus (HPV) infection and its co-factors in the etiology of high-grade cervical neoplasia, and to evaluate new cervical cancer screening technologies. *Note: All published information has been collected from the article referenced in the Marker Paper box below. Therefore, there may be variations with more advanced versions of the study.*
Start Year
National Cancer Institute


Investigators Contacts
  • Dr. Mark Schiffman
    National Institutes of Health


Study design
Population cohort
Follow Up
The cohort will be followed actively, at intervals of no more than a year, to study the natural history of HPV infection. Women were followed longitudinally for seven years.

Marker Paper

Herrero R, Schiffman MH, Bratti C, Hildesheim A, Balmaceda I, Sherman ME, Greenberg M, Cárdenas F, Gómez V, Helgesen K, Morales J, Hutchinson M, Mango L, Alfaro M, Potischman NW, Wacholder S, Swanson C, Brinton LA. Design and methods of a population-based natural history study of cervical neoplasia in a rural province of Costa Rica: the Guanacaste Project. Rev Panam Salud Publica. 1997 May;1(5):362-75. doi: 10.1590/s1020-49891997000500005.


Sources of Recruitment
  • Individuals

Number of participants

Number of participants
Number of participants with biosamples
Supplementary Information
Women 18 years of age


Availability of data and biosamples