Individual Study / Golestan Cohort Study

Golestan Cohort Study

Golestan Cohort Study

Initiatives -
This cohort study is evaluating the environmental and genetic risk factors for esophageal squamous cell carcinoma (ESCC) in Golestan Province, Iran. The primary aims of the GCS are: * To identify risk factors for oesophageal cancer (OC) by a comprehensive assessment of ethnicity, occupational history, socio-economic status, past medical history, family history of cancers, gastrointestinal symptoms and signs, tobacco, opium and alcohol use, oral health, anthropometric characteristics, physical activity and tea drinking habits, including tea temperature. Nutritional patterns are also evaluated * To establish biospecimen banks for blood, urine, hair and nail samples to be used in molecular and genetic studies of cross-sectional or nested case–control design. * To provide a model for population-based studies in a country in economic and social transition based on collaboration between local health workers, local health authorities, national research centres, national government and international research institutions. *Note: All published information has been collected from the article referenced in the Marker Paper box below. Therefore, there may be variations with more advanced versions of the study.*
Start Year
End Year
Tehran University/Medical Sciences (81/15 to R.M., Principal Investigator); Cambridge University (Cancer Research UK, C20/A5860 to B.P., N.D., Principal Investigators); the intramural research program of the NCI, National Institutes of Health; the IARC.
Visit Golestan Cohort Study


Investigators Contacts
  • Dr. Reza Malekzadeh
    Tehran University of Medical Sciences | TUMS
  • Dr. Paolo Boffetta
    Icahn School of Medicine at Mount Sinai
  • Dr. Prof. Farin Kamangar
    Morgan State University


Study design
Population cohort
Follow Up
All participants are being followed up actively every 12 months. The follow-up is expected to continue for a minimum of 10 years.
Supplementary Information

Marker Paper

Pourshams A, Khademi H, Malekshah AF, Islami F, Nouraei M, Sadjadi AR, Jafari E, Rakhshani N, Salahi R, Semnani S, Kamangar F, Abnet CC, Ponder B, Day N, Dawsey SM, Boffetta P, Malekzadeh R. Cohort Profile: The Golestan Cohort Study--a prospective study of oesophageal cancer in northern Iran. Int J Epidemiol. 2010 Feb;39(1):52-9. doi: 10.1093/ije/dyp161. Epub 2009 Mar 30

PUBMED 19332502


Sources of Recruitment
  • Individuals

Number of participants

Number of participants
Number of participants with biosamples
Supplementary Information
The study population is a sample of the Golestan population, aged 40-75 years.


Availability of data and biosamples