Individual Study / Generation XXI

Generation XXI

Generation XXI

Generation XXI logo
Initiatives -
Generation XXI is the first Portuguese birth cohort and intends to characterize prenatal and postnatal development, identifying its determinants in order to understand the state of health in childhood and later in adolescence and adult age. Thus, Generation XXI aims at attaining novel and useful knowledge for understanding the Portuguese reality.   ****
Start Year
Saúde XXI. Programa Operacional Saúde., ARS Norte. Administracao Regional de Saúde do Norte, I.P Fundacao para a Ciencia e a Tecnologia and Fundacao Calouste Gulbenkian
Supplementary Information
Visit Generation XXI


Study design
Population cohort
Follow Up
This project aims to follow these children up to adulthood. At 6, 15 and 24 months, sub samples of babies were examined and at 4 years of age, the whole cohort was invited to participate. This evaluation occurred between April 2009 and August 2011. Between April 2012 and March 2014, all participants were once again invited to participate, and this evaluation at 7 years of age, and the last wave when children are 10 years old.

Marker Paper

Larsen PS, Kamper-Jørgensen M, Adamson A, et al. Pregnancy and birth cohort resources in europe: a large opportunity for aetiological child health research [published correction appears in Paediatr Perinat Epidemiol. 2013 Sep;27(5):505. Charles, Marie-Aline[added]]. Paediatr Perinat Epidemiol. 2013;27(4):393-414. doi:10.1111/ppe.12060

PUBMED 23772942


Sources of Recruitment
  • Individuals
  • Families

Number of participants

Number of participants
Number of participants with biosamples
Supplementary Information
The recruitment of newborns occurred between April 2005 and August 2006 at the five public maternity units in the metropolitan area of Porto.


Availability of data and biosamples


Availability of access information

On the study website :