Genetics of ARthritis en Progression
Initiatives
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To gain further insight in clinical, genetic, biochemical and radiographic parameters that are associated with the development and progression of osteoarthritis
- Start Year
- 2000
- End Year
- 2005
Visit GARP
| Investigators | Contacts |
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Design
- Study design
- Patients' cohort
- Follow Up
- Baseline study in which 200 sib pairs participate (2000-2003) and the progression study in which 100 sib pairs are followed for 2 year (2002-2005). Between 2007 and 2008 all patients will be evaluated again after an average of 5 years.
Marker Paper
Meulenbelt I, Bos SD, Kloppenburg M, Lakenberg N, Houwing-Duistermaat JJ, Watt I, de Craen AJ, van Duijn CM, Slagboom PE. Interleukin-1 gene cluster variants with innate cytokine production profiles and osteoarthritis in subjects from the Genetics, Osteoarthritis and Progression Study. Arthritis Rheum. 2010 Apr;62(4):1119-26. doi: 10.1002/art.27325.
PUBMED 20131253
Recruitment
- Sources of Recruitment
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- Other : Sibling pairs
Number of participants
- Number of participants
- 600
- Number of participants with biosamples
- Supplementary Information
- The GARP study is a prospective observational study in patients with familial generalized osteoarthritis or hand osteoarthritis at middle age. All patients have symptoms and definite radiological signs of osteoarthritis and represent an advanced disease state.
Access
Availability of data and biosamples
| Data | |
| Biosamples | |
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Availability of access information
On the study website : https://www.lumc.nl/org/reumatologie/research/a...