Individual Study / GARP

Genetics of ARthritis en Progression

Genetics of ARthritis en Progression

Initiatives -
To gain further insight in clinical, genetic, biochemical and radiographic parameters that are associated with the development and progression of osteoarthritis
Start Year
End Year
Visit GARP


Investigators Contacts
  • Dr. Prof. Ingrid Meulenbelt
    Leiden University Medical Center


Study design
Patients' cohort
Follow Up
Baseline study in which 200 sib pairs participate (2000-2003) and the progression study in which 100 sib pairs are followed for 2 year (2002-2005). Between 2007 and 2008 all patients will be evaluated again after an average of 5 years.

Marker Paper

Meulenbelt I, Bos SD, Kloppenburg M, Lakenberg N, Houwing-Duistermaat JJ, Watt I, de Craen AJ, van Duijn CM, Slagboom PE. Interleukin-1 gene cluster variants with innate cytokine production profiles and osteoarthritis in subjects from the Genetics, Osteoarthritis and Progression Study. Arthritis Rheum. 2010 Apr;62(4):1119-26. doi: 10.1002/art.27325.

PUBMED 20131253


Sources of Recruitment
  • Other : Sibling pairs

Number of participants

Number of participants
Number of participants with biosamples
Supplementary Information
The GARP study is a prospective observational study in patients with familial generalized osteoarthritis or hand osteoarthritis at middle age. All patients have symptoms and definite radiological signs of osteoarthritis and represent an advanced disease state.


Availability of data and biosamples


Availability of access information

On the study website :