Individual Study / Bove et al.; Neurol Neuroimmunol Neuroinflamm. 2015

Evaluating More Naturalistic Outcome Measures: A 1-year Smartphone Study in Multiple Sclerosis

Evaluating More Naturalistic Outcome Measures: A 1-year Smartphone Study in Multiple Sclerosis

Initiatives -
In this cohort of individuals with and without multiple sclerosis (MS) some of the novel approaches that smartphones provide to monitor patients with chronic neurologicdisorders in their natural setting was illustrate. Note: All published information has been collected from the article referenced in the Marker Paper box below. Therefore, there may be variations with more advanced versions of the study.
Start Year
2012
Funding
This study was funded by Vertex Pharmaceuticals Incorporated

Design

Study design
Patients' cohort

Marker Paper

Bove R, White CC, Giovannoni G, et al. Evaluating more naturalistic outcome measures: A 1-year smartphone study in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2015;2(6):e162. Published 2015 Oct 15. doi:10.1212/NXI.0000000000000162

PUBMED 26516627

Recruitment

Sources of Recruitment
  • Other : Pairs consisting of 1 patient with demyelinating disease and 1 healthy cohabitant

Number of participants

Number of participants
76
Number of participants with biosamples
Supplementary Information
38 participant pairs (MS and cohabitant)

Access

Availability of data and biosamples

Data
Biosamples
Other

Timeline

Population

Pairs consisting of 1 patient with demyelinating disease and 1 healthy cohabitant, all aged 18–55years, were recruited at the Partners MS Center, a large referralclinical center in the northeastern United States.
Selection Criteria
Minimum age
18
Maximum age
55
Newborns
Twins
Countries
  • United States of America
Ethnic Origin
Health Status
  • Patients with multiple sclerosis (MS)

Recruitment

Sources of recruitment
  • Specific population
Specific Population
  • Clinic patients

Number of participants

Number of participants
76
Number of participants with biosamples
Supplementary Information
Thirty-eight participant pairs (MS and cohabitant) aged 18–55 years participated in thestudy.
Data Collection Event
Each participant received an Android HTC Sensation4G smartphone as well as a free cellular phone service plan for theduration of the study.A custom application suite consisting of 19 tests was designedto (1) assess participant performance (color vision, attention, dex-terity, and cognition), and (2) elicit patient-reported outcomes(PROs; fatigue, mood, and QOL).
Start Date
2012-05
End Date
2014-01
Data sources
  • Mobile data collection
    • Smartphone
    • Smartphone apps