Individual Study / EPIPAGE 2

Étude épidémiologique sur les petits âges gestationnels 2 [epidemiological study on small gestational ages]

Étude épidémiologique sur les petits âges gestationnels 2 [epidemiological study on small gestational ages]

EPIPAGE 2 logo
Initiatives -
1. Learn more about the outcome of very preterm infants and their families; 2. Assess the effects of the organization of care and of medical practices on the health and development of preterm babies; 3. Define the specific needs for care during childhood; 4. Understand the paths families travel; 5. Improve knowledge about the causes of preterm birth; 6. Discover more information about its consequences: by studying the cerebral abnormalities that some children may have and their prognostic value for neurological development and for cognitive function disorders, by analyzing the effect of nutrition and of abnormalities in the development of intestinal flora on the child's health and development and by looking for biomarkers of complications related to preterm birth; 7. Understand and analyze the ethical questions raised by care for extremely preterm children at their birth and in intensive care departments.. **Genaral information:**
Start Year
French Institute of Public Health Research/Instituteof Public Health and its partners the French HealthMinistry, the National Institute of Health andMedical Research, the National Institute of Cancer,and the National Solidarity Fund for Autonomy;grant ANR-11-EQPX-0038 from the NationalResearch Agency through the French EquipexProgram of Investments in the Future; and thePremUp Foundation


Investigators Contacts
  • Dr. Pierre-Yves Ancel
    Institut national de la santé et de la recherche médicale(INSERM)
  • Dr. Valérie Benhammou
    Institut national de la santé et de la recherche médicale


Study design
Population cohort
Follow Up
Follow-ups including questionnaires and assessments when the children are 1, 2, 5, 8 and 12 years old.

Marker Paper

Ancel PY, Goffinet F; EPIPAGE-2 Writing Group, Kuhn P, Langer B, Matis J, Hernandorena X, Chabanier P, Joly-Pedespan L, Lecomte B, Vendittelli F, Dreyfus M, Guillois B, Burguet A, Sagot P, Sizun J, Beuchée A, Rouget F, Favreau A, Saliba E, Bednarek N, Morville P, Thiriez G, Marpeau L, Marret S, Kayem G, Durrmeyer X, Granier M, Baud O, Jarreau PH, Mitanchez D, Boileau P, Boulot P, Cambonie G, Daudé H, Bédu A, Mons F, Fresson J, Vieux R, Alberge C, Arnaud C, Vayssière C, Truffert P, Pierrat V, Subtil D, D'Ercole C, Gire C, Simeoni U, Bongain A, Sentilhes L, Rozé JC, Gondry J, Leke A, Deiber M, Claris O, Picaud JC, Ego A, Debillon T, Poulichet A, Coliné E, Favre A, Fléchelles O, Samperiz S, Ramful D, Branger B, Benhammou V, Foix-L'Hélias L, Marchand-Martin L, Kaminski M. Survival and morbidity of preterm children born at 22 through 34 weeks' gestation in France in 2011: results of the EPIPAGE-2 cohort study. JAMA Pediatr. 2015 Mar;169(3):230-8. doi: 10.1001/jamapediatrics.2014.3351. Erratum in: JAMA Pediatr. 2015 Apr;169(4):323. Alberge, Catherine [Corrected to Alberge, Corine].

PUBMED 25621457


Sources of Recruitment
  • Families
  • Other : Preterm infants

Number of participants

Number of participants
Number of participants with biosamples


Availability of data and biosamples