Individual Study / EPICE

Effective Perinatal Intensive Care In Europe

Effective Perinatal Intensive Care In Europe

EPICE logo
Initiatives -
The EPICE project aimed to: 1. Build an empirical knowledge base about how scientific evidence is translated into health service provision in maternity and neonatal units by: * measuring the use of key medical interventions in clinical settings; * studying the factors associated with adoption of evidence based medical interventions; * providing updated information on the effectiveness of medical practices. 2. Identify catalysts for the uptake of evidence-based practices in units and on the regional level. 3. Develop strategies to achieve change in the delivery of perinatal health care with the participation of front-line clinicians, researchers and policy makers
Start Year
End Year


Investigators Contacts
  • Dr. Jennifer Zeitlin
    Institut national de la santé et de la recherche médicale(INSERM)


Study design
Population cohort
Follow Up
Follow-up assessment at 2 years of age was carried out to obtain information on long term health outcomes in the children included in the cohort. Parents filled in a questionnaire on their children’s growth, motor and cognitive development and health. This follow-up enabled to assess effectiveness of different medical practices and policies by comparing outcomes in terms of survival free from major morbidities at 2 years of age.

Marker Paper

Zeitlin J, Maier RF, Cuttini M, Aden U, Boerch K, Gadzinowski J, Jarreau PH, Lebeer J, Norman M, Pedersen P, Petrou S, Pfeil JM, Toome L, van Heijst A, Van Reempts P, Varendi H, Barros H, Draper ES; EPICE and SHIPS Research Group. Cohort Profile: Effective Perinatal Intensive Care in Europe (EPICE) very preterm birth cohort. Int J Epidemiol. 2020 Apr 1;49(2):372-386. doi: 10.1093/ije/dyz270.

PUBMED 32031620


Sources of Recruitment
  • Families
  • Other : Preterm infants

Number of participants

Number of participants
Number of participants with biosamples


Availability of data and biosamples


Availability of access information

On the study website :