Individual Study / Eisenberger et al.; Transplantation. 2013

Medication Adherence Assessment: High Accuracy of the New Ingestible Sensor System in Kidney Transplants

Medication Adherence Assessment: High Accuracy of the New Ingestible Sensor System in Kidney Transplants

Initiatives -
This open-label single-arm exploratory study evaluated the accuracy of the Ingestible Sensor System (ISS), a novel technology for directly assessing the ingestion of oral medications and treatment adherence. Note: All published information has been collected from the article referenced in the Marker Paper box below. Therefore, there may be variations with more advanced versions of the study.
Start Year
2011
End Year
2011
Funding
The study was cofunded by Novartis and Proteus.

Design

Study design
Clinical trial cohort

Marker Paper

Eisenberger U, Wüthrich RP, Bock A, et al. Medication adherence assessment: high accuracy of the new Ingestible Sensor System in kidney transplants. Transplantation. 2013;96(3):245‐250. doi:10.1097/TP.0b013e31829b7571

PUBMED 23823651

Recruitment

Sources of Recruitment
  • Individuals

Number of participants

Number of participants
20
Number of participants with biosamples

Access

Availability of data and biosamples

Data
Biosamples
Other

Timeline

Population

Twenty patients participated in this 12-week uncontrolled pilot study. Patients were in majority Caucasians (19 of 20), males (15 of 20), and 51.7±8.8 years old (mean±SD; range 35–68) and had a body weight of 81.8±12.7 kg (range, 54.5–105.4). They were in stable condition after an average of 6.0±5.0 years after renal transplantation (range, 1–19 years) and taking ECMPS or mycophenolate mofetil in combination with cyclosporine (7 patients), tacrolimus (11 patients), sirolimus (1 patient), or everolimus (1 patient). Three (15%) patients had a second transplant.
Selection Criteria
Newborns
Twins
Countries
  • Switzerland
Ethnic Origin
Health Status
  • kidney transplants

Recruitment

Sources of recruitment
  • General population

Number of participants

Number of participants
20
Number of participants with biosamples
Data Collection Event
This open-label single-arm exploratory study evaluated the accuracy of the Ingestible Sensor System (ISS), a novel technology for directly assessing the ingestion of oral medications and treatment adherence.
Start Date
2011-05
End Date
2011-11
Data sources
  • Smart sensors
    • Ingestible sensors