Individual Study / ECHO-NOVI

Neonatal Neurobehavior and Outcomes in Very Preterm Infant (ECHO‐NOVI)

Neonatal Neurobehavior and Outcomes in Very Preterm Infant (ECHO‐NOVI)

ECHO-NOVI logo
Initiatives -
* The purpose of this Environmental Influences on Child Health Outcomes (ECHO) application is to leverage our ongoing NIH (1R01HD072267-01A) longitudinal multisite prospective study of approximately 600 infants born < 30 weeks PMA from birth to age 2 entitled “Neonatal Neurobehavior and Outcomes in Very Preterm Infants.” Our long-term goal is to discern which of these infants are most likely to become developmentally impaired, a personalized medicine approach that could lead to interventions that prevent or mitigate later deficits. * About one-third of infants born less than 30 weeks suffer long-term developmental challenges. We hope to identify which infants are more likely to become developmentally impaired and determine whether special types of care in the neonatal intensive care unit (NICU) and early developmental intervention services after discharge could improve the developmental outcomes for premature infants and their families.
Start Year
2016
End Year
2023
Funding
National Institutes of Health (NIH)
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Members

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Investigators Contacts
  • Dr. Prof. Barry M. Lester
    Brown Alpert Medical School and Women and Infants Hospital

Design

Study design
Population cohort
Follow Up
In ECHO-NOVI, we plan to follow these children through age seven to further determine potential mechanisms that lead to developmental and child health outcomes.

Marker Paper

Everson TM, Marsit CJ, Michael O'Shea T, Burt A, Hermetz K, Carter BS, Helderman J, Hofheimer JA, McGowan EC, Neal CR, Pastyrnak SL, Smith LM, Soliman A, DellaGrotta SA, Dansereau LM, Padbury JF, Lester BM. Epigenome-wide Analysis Identifies Genes and Pathways Linked to Neurobehavioral Variation in Preterm Infants. Sci Rep. 2019 Apr 19;9(1):6322. doi: 10.1038/s41598-019-42654-4.

PUBMED 31004082

Recruitment

Sources of Recruitment
  • Individuals

Number of participants

Number of participants
600
Number of participants with biosamples

Access

Availability of data and biosamples

Data
Biosamples
Other