Individual Study / Dukart_Proc Natl Acad Sci USA_2014

Electroconvulsive therapy-induced brain plasticity determines therapeutic outcome in mood disorders (The GEMRIC centers in Lausanne, Switzerland and Berlin, Germany)

Electroconvulsive therapy-induced brain plasticity determines therapeutic outcome in mood disorders (The GEMRIC centers in Lausanne, Switzerland and Berlin, Germany)

Initiatives -
"This study shows differential, highly specific, spatially distributed effects of ECT on regional brain structure in two populations: patients with unipolar or bipolar disorder. Unipolar and bipolar disorders respond differentially to ECT and the associated local brain-volume changes, which occur in areas previously associated with these diseases, correlate with symptom severity and the therapeutic effect. The evidence demonstrate that electrophysical therapeutic effects, although applied generally, take on regional significance through interactions with brain pathophysiology."
Visit Dukart_Proc Natl Acad Sci USA_2014

Members

Download
Investigators Contacts
  • Dr. Bogdan Draganski
    Centre Hospitalier Universitaire Vaudois, Université de Lausanne

Design

Study design
Patients' cohort

Marker Paper

Dukart J, Regen F, Kherif F, et al. Electroconvulsive therapy-induced brain plasticity determines therapeutic outcome in mood disorders. Proc Natl Acad Sci USA. 2014;111(3):1156-1161. doi:10.1073/pnas.1321399111

PUBMED 24379394

Recruitment

Sources of Recruitment
  • Individuals

Number of participants

Number of participants
10
Number of participants with biosamples

Access

Availability of data and biosamples

Data
Biosamples
Other

Availability of access information

On the study website : https://mmiv.no/gemric/