Cumulative effects of prenatal stress and chemical exposures on child development
Initiatives
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We propose to integrate two pregnancy cohorts currently under recruitment at the University of Illinois and the University of California, San Francisco (UCSF) to form a larger geographically, socio-economically, racially and ethnically diverse cohort (ECHO.CA.IL) to study the cumulative impact of chemical exposures and maternal psychosocial stress on birth outcomes and early neurodevelopment. We will address three specific aims:
1. Evaluate the relationship between prenatal exposures to EDCs and measures of adverse birth outcomes and cognitive development of offspring.
2. Evaluate the relationship between measures of prenatal stress and measures of adverse birth outcomes and cognitive development of offspring. Importantly, for this aim we will also assess whether biomarkers of stress response mediate the relationship between perceptual and place-based stress and developmental outcomes.
3. Evaluate whether maternal stress modifies observed relationships between EDC exposures and measures of adverse birth outcomes or cognitive development of offspring
- Start Year
- 2016
- End Year
- 2023
- Funding
- National Institutes of Health
Visit Cumulative effects of prenatal stress and chemical exposures on child development
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Design
- Study design
- Population cohort
Marker Paper
Tran KV, Casey JA, Cushing LJ, Morello-Frosch R. Residential Proximity to Oil and Gas Development and Birth Outcomes in California: A Retrospective Cohort Study of 2006-2015 Births. Environ Health Perspect. 2020 Jun;128(6):67001. doi: 10.1289/EHP5842. Epub 2020 Jun 3.
PUBMED 32490702
Recruitment
- Sources of Recruitment
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- Families
Number of participants
- Number of participants
- Number of participants with biosamples
Access
Availability of data and biosamples
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