European Childhood Obesity Project
Initiatives
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1. To test the primary hypothesis that a possible causal factor for the difference in long-term obesity risk between breast and formula fed infants is the much lower protein content of breast milk compared to infant formulae.
2. To do this by performing a double blind randomised multicentre intervention trial in healthy infants, comparing isocaloric infant formulae with high and low protein contents, balanced by fat.
3. To validate the primary hypothesis with epidemiological observational studies evaluating the effects of different habitual protein intakes with traditional complementary feeding regimes in infants in the same 5 countries.
4. To evaluate the relationship between different types of infant feeding regimes on a novel, early anthropometric marker, namely the difference between length at two years and length at birth, or later obesity development.
5. To investigate the effects of these infant feeding regimes on body composition, energy expenditure, physical activity, protein metabolism, renal function, leptin and its binding protein and on insulin like growth factor1.
6. To disseminate the results widely to the user communities.
7. To explore effective preventive strategies by modification of the composition and use of dietary products for infants and thus contribute to significant potential health benefits for the European population.
- Start Year
- 2002
- End Year
- 2015
- Funding
- Partially supported by: the Commission of the European Community, specific RTD Programme ‘Quality of Life and Management of Living Resources’ within the 5th Framework Programme (research grant nos. QLRT-2001–00389 and QLK1-CT-2002–30582); the 6th Framework Programme (contract no. 007036); the European Union’s Seventh Framework Programme(FP7/2007–2013), project EarlyNutrition under grant agreement no. 289346; and the European Research Council Advanced grant ERC-2012-AdG – no.322605 META-GROWTH.
- Supplementary Information
- https://clinicaltrials.gov/ct2/show/NCT00338689
Visit CHOP
| Investigators | Contacts |
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Design
- Study design
- Clinical trial cohort
- Follow Up
- Follow-up until age 8 years by three-day estimated and weighed food diaries were completed by the child’s parent or caregiver at theages of 1, 2, 3, 4, 5, 6 and 8 years.
Marker Paper
Marsh, K., Möller, J., Basarir, H., Orfanos, P., & Detzel, P. (2016). The Economic Impact of Lower Protein Infant Formula for the Children of Overweight and Obese Mothers. Nutrients, 8(1), 18. https://doi.org/10.3390/nu8010018
PUBMED 19386747
Recruitment
- Sources of Recruitment
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- Families
- Other : Pregnant women and their newborns.
Number of participants
- Number of participants
- 1,678
- Number of participants with biosamples
- Supplementary Information
- 1678 mothers
Access
Availability of data and biosamples
| Data | |
| Biosamples | |
| Other |