Individual Study / CASPER

Cognition and Affect after Stroke: Prospective Evaluation of Risks

Cognition and Affect after Stroke: Prospective Evaluation of Risks

Initiatives -
* To examine whether stroke-specific (e.g. lesion location, volume, type, severity), cerebrovascular and neurodegenerative (e.g. white matter changes, atrophy, microbleeds, perivascular spaces), inflammatory, endothelial, and (epi)genetic markers are associated with cognitive impairment, post-stroke depression, and post-stroke apathy, and whether they predict their course over 12 months. * The secondary aims are to investigate how the above-mentioned markers interact with each other, and to determine if patients with apathy and depression after stroke differ in pathogenesis, course, and outcome (e.g. functional outcome, neurocognitive performance, quality of life). *Note: All published information has been collected from the article referenced in the Marker Paper box below. Therefore, there may be variations with more advanced versions of the study.*
Start Year
End Year
his project was funded by Maastricht University, Health Foundation Limburg, and the Adriana van Rinsum-Ponsen Stichting.


Investigators Contacts
  • Dr. Prof. Sebastian Köhler
    School for Mental Health and Neuroscience


Study design
Patients' cohort
Follow Up
6m after baseline (9m after stroke), 12m after baseline (15m after stroke)

Marker Paper

Douven, E., Schievink, S., Verhey, F.R.J. et al. The Cognition and Affect after Stroke - a Prospective Evaluation of Risks (CASPER) study: rationale and design. BMC Neurol 16, 65 (2016).


Sources of Recruitment
  • Individuals

Number of participants

Number of participants
Number of participants with biosamples
Supplementary Information
Over 40 years old


Availability of data and biosamples