Carotene and Retinol Efficacy Trial
Initiatives
-
To evaluate the efficacy and safety of a daily combination of 30 mg of beta-carotene plus 25,000 ID of retinyl palmitate for Chemoprevention of Lung
Cancer in High Risk Populations: Smokers and Asbestos-exposed Workers.
*Note: All published information has been collected from the article referenced in the Marker Paper box below. Therefore, there may be variations with more advanced versions of the study.*
- Start Year
- 1985
- End Year
- 2005
| Investigators | Contacts |
|---|---|
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Design
- Study design
- Clinical trial cohort
- Follow Up
- In the first year after randomization, efficacy participants are contacted four times, by telephone at 3 and 9 months and by visits to the study center at 6 and 12 months. In subsequent years, efficacy participants are contacted by telephone at 4 and 8 months past the randomization anniversary date and have an annual visit at the study center. The active vanguard group is monitored more closely, with semiannual visits.
Marker Paper
Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., ... & Hammar, S. (1996). Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. New England journal of medicine, 334(18), 1150-1155.
PUBMED 8137335
Recruitment
- Sources of Recruitment
-
- Individuals
Number of participants
- Number of participants
- 18,341
- Number of participants with biosamples
- Supplementary Information
- Persons at high risk of lung cancer
Access
Availability of data and biosamples
| Data | |
| Biosamples | |
| Other |