Individual Study / CARET

Carotene and Retinol Efficacy Trial

Carotene and Retinol Efficacy Trial

Initiatives -
To evaluate the efficacy and safety of a daily combination of 30 mg of beta-carotene plus 25,000 ID of retinyl palmitate for Chemoprevention of Lung Cancer in High Risk Populations: Smokers and Asbestos-exposed Workers. *Note: All published information has been collected from the article referenced in the Marker Paper box below. Therefore, there may be variations with more advanced versions of the study.*
Start Year
1985
End Year
2005

Members

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Investigators Contacts
  • MD Gary E. Goodman
    Fred Hutchinson Cancer Research Center

Design

Study design
Clinical trial cohort
Follow Up
In the first year after randomization, efficacy participants are contacted four times, by telephone at 3 and 9 months and by visits to the study center at 6 and 12 months. In subsequent years, efficacy participants are contacted by telephone at 4 and 8 months past the randomization anniversary date and have an annual visit at the study center. The active vanguard group is monitored more closely, with semiannual visits.

Marker Paper

Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., ... & Hammar, S. (1996). Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. New England journal of medicine, 334(18), 1150-1155.

PUBMED 8137335

Recruitment

Sources of Recruitment
  • Individuals

Number of participants

Number of participants
18,341
Number of participants with biosamples
Supplementary Information
Persons at high risk of lung cancer

Access

Availability of data and biosamples

Data
Biosamples
Other