Individual Study / CANVAS

Cognition and Neocortical Volume After Stroke Study

Cognition and Neocortical Volume After Stroke Study

Initiatives -
The study aims to establish whether brain volume change is associated with poststroke dementia, and to elucidate potential causal mechanisms, including genetic markers, amyloid deposition and vascular risk factors. An understanding of whether - and in whom - stroke is neurodegenerative is critical for the strategic use of potential disease-modifying therapies. *Note: All published information has been collected from the article referenced in the Marker Paper box below. Therefore, there may be variations with more advanced versions of the study.*
Start Year
End Year


Investigators Contacts
  • Dr. Amy Brodtmann
    Florey Institute for Neuroscience and Mental Health


Study design
Patients' cohort
Follow Up
Participants were followed up at three-months, 12 months and three years.

Marker Paper

Brodtmann A, Werden E, Pardoe H, Li Q, Jackson G, Donnan G, Cowie T, Bradshaw J, Darby D, Cumming T. Charting cognitive and volumetric trajectories after stroke: protocol for the Cognition And Neocortical Volume After Stroke (CANVAS) study. Int J Stroke. 2014 Aug;9(6):824-8. doi: 10.1111/ijs.12301. Epub 2014 Jun 3. .

PUBMED 24894387


Sources of Recruitment
  • Individuals

Number of participants

Number of participants
Number of participants with biosamples
Supplementary Information
Over 18 years old. 3 (Melbourne hospital stroke units)


Availability of data and biosamples