Breakthrough Generations Study
Initiatives
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To investigate the complex interplay of lifestyle, environmental, genetic and hormonal factors acting throughout a woman’s life and determine how these affect an individual’s risk of developing breast cancer.
- Start Year
- 2002
- Funding
- Breakthrough Breast Cancer and the Institute of Cancer Research
Visit Breakthrough Generations Study
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Design
- Study design
- Population cohort
- Follow Up
- Follow-up data on site-specific cancer incidence, other major disease occurrence, breast disease and cause-specific mortality are obtained via several sources. First, we receive spontaneous reports from cohort members about the occurrence of breast and other cancers, and from their husbands/partners or other relatives about deaths. Secondly, annual newsletters are sent to the cohort members, and if these are returned as undeliverable, we then ascertain vital status using the methods described below and (if alive) track a current address via the sources below. Thirdly, at intervals of about 2 and a half years since enrolment, participants are sent follow-up questionnaires.
Marker Paper
Swerdlow AJ, Jones ME, Schoemaker MJ, Hemming J, Thomas D, Williamson J, Ashworth A. The Breakthrough Generations Study: design of a long-term UK cohort study to investigate breast cancer aetiology. Br J Cancer. 2011 Sep 27;105(7):911-7. doi: 10.1038/bjc.2011.337. Epub 2011 Sep 6.
PUBMED 21897394
Recruitment
- Sources of Recruitment
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- Individuals
Number of participants
- Number of participants
- 113,000
- Number of participants with biosamples
- Supplementary Information
- Women aged 16-102 years
Access
Availability of data and biosamples
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| Biosamples | |
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Availability of access information
On the study website : https://www.breakthroughgenerations.org.uk/home