Individual Study / Breakthrough Generations Study

Breakthrough Generations Study

Breakthrough Generations Study

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Initiatives -
Start Year
Breakthrough Breast Cancer and the Institute of Cancer Research
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Investigators Contacts
  • Michael Jones
    University of Cambridge
  • Prof Anthony Swerdlow
    Institute of Cancer Research


Study design
Population cohort
Follow Up
Follow-up data on site-specific cancer incidence, other major disease occurrence, breast disease and cause-specific mortality are obtained via several sources. First, we receive spontaneous reports from cohort members about the occurrence of breast and other cancers, and from their husbands/partners or other relatives about deaths. Secondly, annual newsletters are sent to the cohort members, and if these are returned as undeliverable, we then ascertain vital status using the methods described below and (if alive) track a current address via the sources below. Thirdly, at intervals of about 2 and a half years since enrolment, participants are sent follow-up questionnaires.

Marker Paper

Swerdlow AJ, Jones ME, Schoemaker MJ, Hemming J, Thomas D, Williamson J, Ashworth A. The Breakthrough Generations Study: design of a long-term UK cohort study to investigate breast cancer aetiology. Br J Cancer. 2011 Sep 27;105(7):911-7. doi: 10.1038/bjc.2011.337. Epub 2011 Sep 6.

PUBMED 21897394


Sources of Recruitment
  • Individuals

Number of participants

Number of participants
Number of participants with biosamples
Supplementary Information
Women aged 16-102 years


Availability of data and biosamples


Availability of access information

On the study website :