Individual Study / Birmingham-Black Country-Atrial Fibrillation registry

Birmingham-Black Country-Atrial Fibrillation registry

Birmingham-Black Country-Atrial Fibrillation registry

Initiatives -
Patients with and without AF. Blood based biomarkers and ECG markers were compared between the two groups of patients. The blood based biomarker analysis using a novel proteomics chip technique demonstrated that BNP and a novel biomarker, fibroblast growth factor 23 (FGF-23) were increased in AF patients and were also independently predictive of AF.
Start Year
2014
End Year
2016
Funding
University of Birmingham and The European Network for Translational Research in Atrial Fibrillation (EUTRAF)

Members

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Investigators Contacts
  • Dr. Paulus Kirchhof
    University of Birmingham

Design

Study design
Patients' cohort

Marker Paper

Chua, W., Purmah, Y., Cardoso, V. R., Gkoutos, G. V., Tull, S. P., Neculau, G., Thomas, M. R., Kotecha, D., Lip, G., Kirchhof, P., & Fabritz, L. (2019). Data-driven discovery and validation of circulating blood-based biomarkers associated with prevalent atrial fibrillation. European heart journal, 40(16), 1268–1276. https://doi.org/10.1093/eurheartj/ehy815

PUBMED 30615112

Recruitment

Sources of Recruitment
  • Individuals

Number of participants

Number of participants
800
Number of participants with biosamples

Access

Availability of data and biosamples

Data
Biosamples
Other