Individual Study / BIOMarCS

BIOMarker study to identify the Acute risk of a Coronary Syndrome

BIOMarker study to identify the Acute risk of a Coronary Syndrome

Initiatives -
Evaluate whether biomarker patterns of (vascular) inflammation, distorted lipid metabolism, endothelial dysfunction, decreased endothelial regenerative capacity, increased thrombo-genicity and ischaemia diverge in days to weeks prior to an acute coronary syndrome (ACS). *Note: All published information has been collected from the article referenced in the Marker Paper box below. Therefore, there may be variations with more advanced versions of the study.*
Start Year
End Year
Netherlands Heart Foundation (grant number 2007B012), the Netherlands Heart Institute-Interuniversity Cardiology Institute of the Netherlands (project number 071.01) and the Working Group on Cardiovascular Research Netherlands, all of which are non-commercial funding bodies. An unrestricted research grant is further obtained from Eli Lilly, the Netherlands. FWA is supported by a Dekker scholarship-Junior Staff Member 2014T001—the Netherlands Heart Foundation and UCL Hospitals NIHR Biomedical Research Centre


Investigators Contacts
  • Dr. Prof. Eric Boersma
    Erasmus MC


Study design
Patients' cohort
Follow Up
Blood samples were collected at admission, at the day of hospital discharge and subsequently every fortnight during the first 6 months after discharge, followed by monthly blood sample collection until 1 year. Patients were offered some flexibility in the follow-up scheme: visit windows are±1 week, and a maximum of two consecutive visits are allowed to be skipped (for personal reasons). 15 years follow-up.

Marker Paper

Oemrawsingh RM, Akkerhuis KM, Umans VA, Kietselaer B, Schotborgh C, Ronner E, Lenderink T, Liem A, Haitsma D, van der Harst P, Asselbergs FW, Maas A, Oude Ophuis AJ, Ilmer B, Dijkgraaf R, de Winter RJ, The SH, Wardeh AJ, Hermans W, Cramer E, van Schaik RH, Hoefer IE, Doevendans PA, Simoons ML, Boersma E. Cohort profile of BIOMArCS: the BIOMarker study to identify the Acute risk of a Coronary Syndrome-a prospective multicentre biomarker study conducted in the Netherlands. BMJ Open. 2016 Dec 23;6(12):e012929. doi: 10.1136/bmjopen-2016-012929.

PUBMED 28011810


Sources of Recruitment
  • Individuals

Number of participants

Number of participants
Number of participants with biosamples


Availability of data and biosamples