Individual Study / AGNES

Arrhythmia Genetics in The Netherlands

Arrhythmia Genetics in The Netherlands

Initiatives -
The AGNES case-control set consists of individuals with a first acute ST-elevation myocardial infarction. AGNES cases have ECG- registered ventricular fibrillation occurring before reperfusion therapy for an acute and first ST-elevation myocardial infarction. AGNES controls are individuals with a first acute ST-elevation myocardial infarction but without ventricular fibrillation. All cases and controls are recruited at seven heart centers in The Netherlands.
Start Year
2008
Funding
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Visit AGNES

Members

Download
Investigators Contacts
  • Dr. Prof. Connie Bezzina
    Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Design

Study design
Case-control

Marker Paper

Bezzina, C., Pazoki, R., Bardai, A. et al. Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction. Nat Genet 42, 688–691 (2010). https://doi.org/10.1038/ng.623

Recruitment

Sources of Recruitment
  • Individuals

Number of participants

Number of participants
1,433
Number of participants with biosamples
Supplementary Information
Cases are patients with a first ST-elevation myocardial infarction (STEMI). Aged 18 to 80 years. (672 cases, 761 controls)

Access

Availability of data and biosamples

Data
Biosamples
Other