Individual Study / 3C Study

French Three-City Study

French Three-City Study

3C Study logo
Initiatives -
The principal objective of the 3C-Study is to estimate the risk of dementia (Alzheimer’s disease and other types) that may be attributed to vascular factors. To reach this general objective, the following specific objectives must be attained: 1. To assess the associations of vascular diseases (CHD and stroke) with dementia and cognitive impairment; 2. To quantify the associations between cerebral white matter hyperintensities and dementia; 3. To quantify the associations of dementia with factors that increase or decrease the risk of vascular diseases; 4. To quantify the associations of cerebral measures (white matter hyperintensities and atrophy) with factors that increase or decrease the risk of vascular diseases.
Start Year
End Year
The Fondation pour la Recherche Médicale funded the preparation and initiation ofthe study. The 3C Study is also supported by the Caisse Nationale Maladie des Travailleurs Salariés, Direction Générale de la Santé,Conseils Régionaux of Aquitaine, Languedoc-Roussillon and Bourgogne, Fondation de France, Ministry of Research-INSERM Programme ‘Cohortes et collections de données biologiques’, Mutuelle Générale de l’Education Nationale, Institut de la longévité, Conseil Général de la Côte d’or.
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Investigators Contacts
  • MD, Dr Christophe Tzourio
    Bordeaux Population Health Research Center


Study design
Population cohort
Follow Up
Participants have been re-examined, on the average, every two years. Each follow-up examination includes a labour-intensive ascertainment of the main outcomes of the study. Dementia, coronary heart disease (CHD) and stroke cases are validated by panels of independent experts.

Marker Paper

3C Study Group. Vascular factors and risk of dementia: design of the Three-City Study and baseline characteristics of the study population. Neuroepidemiology. 2003 Nov-Dec;22(6):316-25. doi: 10.1159/000072920.

PUBMED 14598854


Sources of Recruitment
  • Individuals

Number of participants

Number of participants
Number of participants with biosamples


Availability of data and biosamples